Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3069698 | 0.81 | CHEK1 (1.00) | CHEK1KCNH2 | |
| SCHEMBL3082469 | 0.78 | CHEK1 (0.79) | CHEK1KCNH2 | |
| SCHEMBL4347178 | 0.78 | CHEK1 (1.00) | CHEK1KCNH2 | |
| SCHEMBL3064129 | 0.77 | CHEK1 (0.79) | CHEK1KCNH2 | |
| SCHEMBL3064124 | 0.77 | CHEK1 (0.79) | CHEK1KCNH2 | |
| SCHEMBL3064132 | 0.77 | CHEK1 (0.79) | CHEK1KCNH2 | |
| SCHEMBL27723937 | 0.75 | CHEK1 (0.78) | CHEK1KCNH2 | |
| SCHEMBL27723942 | 0.74 | CHEK1 (0.74) | CHEK1KCNH2 | |
| SCHEMBL27703359 | 0.73 | CHEK1 (0.79) | CHEK1KCNH2 | |
| SCHEMBL5811825 | 0.72 | CHEK1 (0.61) | CHEK1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2144630-A2 | CHK1 INHIBITORS WITH B CELL DEPLETING ANTIBODIES FOR THE TREATMENT OF HEMATOLOGIC MALIGNANCIES | AstraZeneca AB (SE) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008132500-A2 | CHKL INHIBITORS WITH B CELL DEPLETING ANTIBODIES FOR THE TREATMENT OF HEMATOLOGIC MALIGNANCIES | ASTRAZENECA AB (SE) | 2008-11-06 | — | — | WO | disclosed |