Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 8/20 | 0.44 |
| ▸ | NOS2 | P35228 | 8/20 | 0.44 |
| ▸ | NOS1 | P29475 | 6/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | CCR8 | P51685 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
| ▸ | AGXT | P21549 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14353700 | 0.83 | NOS3 (0.44) | NOS3NOS2NOS1KDM4EKMT2A | |
| SCHEMBL5809638 | 0.81 | NOS3 (0.46) | NOS3NOS2NOS1POLBKDM4E | |
| SCHEMBL3840770 | 0.81 | NOS3 (0.42) | NOS3NOS2NOS1POLBKDM4E | |
| Ammonia Solution, Strong SCHEMBL29016866 | 0.79 | NOS3 (0.44) | NOS3NOS2NOS1POLBKDM4E | |
| SCHEMBL3190363 | 0.78 | UHRF1 (0.42) | NOS3NOS2NOS1KDM4EKMT2A | |
| SCHEMBL25604971 | 0.77 | NOS3 (0.39) | NOS3NOS2NOS1POLBKMT2A | |
| SCHEMBL9455862 | 0.77 | NOS3 (0.39) | NOS3NOS2NOS1KDM4EKMT2A | |
| SCHEMBL7453220 | 0.77 | NOS3 (0.39) | NOS3NOS2NOS1KDM4EKMT2A | |
| SCHEMBL874915 | 0.77 | CCR1 (0.46) | NOS3NOS2NOS1CCR1CCR5 | |
| Ammonia Solution, Strong SCHEMBL28562820 | 0.74 | CCR1 (0.44) | NOS3NOS2NOS1CCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111032029-A | Vascular adhesion protein-1 inhibitors for the prevention or treatment of migraine | 普罗克斯马根有限责任公司 | 2020-04-17 | — | — | CN | claimed |
| CN-105189494-B | Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors | 普罗克西梅根有限公司 | 2017-04-26 | — | — | CN | claimed |
| CN-105189494-A | Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors | PROXIMAGEN LTD | 2015-12-23 | — | — | CN | claimed |
| CN-101981031-A | Tricyclic compounds having corticotropin-releasing factor antagonistic activity and pharmaceutical compositions containing them | TAKEDA PHARMACEUTICAL | 2011-02-23 | — | — | CN | claimed |
| CN-105916503-B | Heteroaryl compounds and uses thereof | 米伦纽姆医药公司 | 2020-04-14 | — | — | CN | disclosed |
| EP-2500348-B1 | PHOSPHOLIPID DERIVATIVE AND PH-RESPONSIVE LIPOSOMES | NOF CORP (JP) | 2017-08-23 | — | — | EP | disclosed |
| CN-105916503-A | Heteroaryls and uses thereof | 米伦纽姆医药公司 | 2016-08-31 | — | — | CN | disclosed |
| CN-105189494-A | Imidazo[4,5-c]pyridine and pyrrolo[2,3-c]pyridine derivatives as SSAO inhibitors | PROXIMAGEN LTD | 2015-12-23 | — | — | CN | disclosed |
| CN-104125946-A | 6-aminopyridine-3-ol derivatives or pharmaceutically acceptable salts thereof, and pharmaceutical composition containing same as active ingredients for preventing or treating diseases caused by angiogenesis | UNIV YEUNGNAM IACF | 2014-10-29 | — | — | CN | disclosed |
| EP-2240485-B1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL (JP) | 2014-10-15 | — | — | EP | disclosed |
| US-8445712-B2 | Phospholipid derivative and pH-responsive liposomes | NOF CORPORATION (JP) | 2013-05-21 | — | — | US | disclosed |
| US-20120258165-A1 | PHOSPHOLIPID DERIVATIVE AND PH-RESPONSIVE LIPOSOMES | OSAKA PREFECTURE UNIVERSITY PUBLIC CORPORATION (JP) | 2012-10-11 | — | — | US | disclosed |
| EP-2500348-A1 | PHOSPHOLIPID DERIVATIVE AND PH-RESPONSIVE LIPOSOMES | NOF Corporation (JP) | 2012-09-19 | — | — | EP | disclosed |
| CN-101981031-A | Tricyclic compounds having corticotropin-releasing factor antagonistic activity and pharmaceutical compositions containing them | TAKEDA PHARMACEUTICAL | 2011-02-23 | — | — | CN | disclosed |
| EP-2240485-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Pharmaceutical Company Limited (JP) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009093747-A1 | TRICYCLIC COMPOUNDS HAVING CORTICOTROPIN-RELEASING FACTOR ANTAGONISTIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258165-A1 | PHOSPHOLIPID DERIVATIVE AND PH-RESPONSIVE LIPOSOMES | PHOSPHO1, SGMS1, PLTP | NOS3 2740/4885NOS2 2227/4885NOS1 2157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.