Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TKT | P29401 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.30 |
| ▸ | TUBB | P07437 | 1/20 | 0.30 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.30 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.30 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.30 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.30 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.30 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.30 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.30 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.30 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.30 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.30 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31644177 | 0.83 | MEN1 (0.41) | TKTMEN1KMT2ACHRNB2CHRNA4 | |
| SCHEMBL3509762 | 0.83 | MEN1 (0.41) | TKTMEN1KMT2ACHRNB2CHRNA4 | |
| SCHEMBL10282395 | 0.82 | ALDH1A1 (0.35) | TKTCHRNB2CHRNA4KDM4EALDH1A1 | |
| SCHEMBL845810 | 0.79 | TKT (0.39) | TKTKDM4EALDH1A1PDCD1LG2CD274 | |
| SCHEMBL30492965 | 0.79 | TKT (0.39) | TKTKDM4EALDH1A1PDCD1LG2CD274 | |
| SCHEMBL11039336 | 0.78 | TKT (0.35) | TKTMEN1KMT2A | |
| SCHEMBL403867 | 0.77 | KMT2A (0.39) | TKTKMT2ACHRNB2CHRNA4KDM4E | |
| SCHEMBL29421763 | 0.77 | KMT2A (0.39) | TKTKMT2ACHRNB2CHRNA4KDM4E | |
| SCHEMBL9269242 | 0.77 | CTRC (0.38) | TKTKMT2ACHRNB2CHRNA4TUBB4A | |
| SCHEMBL25679594 | 0.77 | CD274 (0.49) | KMT2APDCD1LG2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | disclosed |