SCHEMBL3671831

SCHEMBL3671831

c1cc2nocc2cn1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3672335 0.82
SCHEMBL2051823 0.70 MAPK10 (0.44)
SCHEMBL12818436 0.69
SCHEMBL30274601 0.68 PDE3B (0.36)
Benzo[C]Isoxazole SCHEMBL22579004 0.68 NPC1 (0.41)
Benzo[C]Isoxazole SCHEMBL27845401 0.67 NPC1 (0.43)
Benzo[C]Isoxazole SCHEMBL1833459 0.67 RAB9A (0.43)
Naphthalene SCHEMBL1879779 0.67 NPC1 (0.43)
SCHEMBL255425 0.65 CLK1 (0.48)
Benzo[C]Isoxazole SCHEMBL28208572 0.65 RAB9A (0.42)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4219465-A2 PRMT5 INHIBITORS AND USES THEREOF Epizyme Inc (US) 2023-08-02 EP disclosed
EP-3498701-B1 PRMT5 INHIBITORS AND USES THEREOF EPIZYME INC (US) 2023-02-22 EP disclosed
EP-3752492-B1 FUNGICIDAL OXADIAZOLES BAYER AG (DE) 2022-12-21 EP disclosed
US-11197857-B2 Combination therapy GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2021-12-14 US disclosed
US-11185531-B2 Arginine methyltransferase inhibitors and uses thereof Epizyme, Inc. (US) 2021-11-30 US disclosed
US-20210078951-A1 ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF Epizyme, Inc. 2021-03-18 US disclosed
US-20210009541-A1 FUNGICIDAL OXADIAZOLES BAYER AKTIENGESELLSCHAFT (DE) 2021-01-14 US disclosed
WO-2020254494-A1 FUNGICIDAL OXADIAZOLES BAYER AKTIENGESELLSCHAFT (DE) 2020-12-24 WO disclosed
WO-2020254488-A1 HYDROXYISOXAZOLINES AND USE THEREOF AS FUNGICIDES BAYER AKTIENGESELLSCHAFT (DE) 2020-12-24 WO disclosed
WO-2020254493-A1 THIENYLHYDROXYISOXAZOLINES AND DERIVATIVES THEREOF BAYER AKTIENGESELLSCHAFT (DE) 2020-12-24 WO disclosed
WO-2014100734-A1 PRMT5 INHIBITORS AND USES THEREOF Epizyme, Inc. (US) 2014-06-26 WO disclosed
WO-2014100730-A1 PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF Epizyme, Inc. (US) 2014-06-26 WO disclosed
US-8299262-B2 Pyridylmethyl-sulfonamide compounds BASF SE (DE) 2012-10-30 US disclosed
WO-2010139653-A1 FUNGICIDAL MIXTURES COMPRISING HETERAROMATIC SULFONAMIDES BASF SE (DE) 2010-12-09 WO disclosed
US-20100249077-A1 Pyridylmethyl-Sulfonamide Compounds BASF SE (DE) 2010-09-30 US disclosed
EP-2231605-A1 PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS BASF SE (DE) 2010-09-29 EP disclosed
WO-2009071448-A1 PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS BASF SE (DE) 2009-06-11 WO disclosed
WO-2009071449-A1 PYRIDYLMETHYL-SULFONAMIDE COMPOUNDS BASF SE (DE) 2009-06-11 WO disclosed
US-7320994-B2 Triazole derivatives as tachykinin receptor antagonists ELI LILLY AND COMPANY (US) 2008-01-22 US disclosed
US-20050239786-A1 Triazole derivatives as tachykinin receptor antagonists ELI LILLY COMPANY (US) 2005-10-27 US disclosed