Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | NCF1 | P14598 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzo[C]Isoxazole SCHEMBL1833459 | 0.95 | RAB9A (0.43) | NPC1RAB9AMAPTALDH1A1HPGD | |
| Benzo[C]Isoxazole SCHEMBL2493132 | 0.91 | NPC1 (0.41) | NPC1RAB9AMAPTALDH1A1HPGD | |
| Biphenyl SCHEMBL3685922 | 0.89 | NPC1 (0.44) | NPC1RAB9AMAPTALDH1A1HPGD | |
| Benzo[C]Isoxazole SCHEMBL11231055 | 0.85 | RAB9A (0.41) | NPC1RAB9AMAPTALDH1A1HPGD | |
| Benzo[C]Isoxazole SCHEMBL22579004 | 0.85 | NPC1 (0.41) | NPC1RAB9AMAPTALDH1A1HPGD | |
| Benzo[C]Isoxazole SCHEMBL23045175 | 0.85 | NPC1 (0.38) | NPC1RAB9AMAPTALDH1A1HPGD | |
| Benzo[C]Isoxazole SCHEMBL18486460 | 0.85 | RAB9A (0.38) | NPC1RAB9AMAPTALDH1A1HPGD | |
| Benzo[C]Isoxazole SCHEMBL6991289 | 0.80 | KDM4E (0.47) | NPC1RAB9AMAPTALDH1A1KDM4E | |
| Benzo[C]Isoxazole SCHEMBL8468373 | 0.80 | KDM4E (0.47) | NPC1RAB9AMAPTALDH1A1KDM4E | |
| Benzo[C]Isoxazole SCHEMBL30292819 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550753-B2 | Mono quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2017-01-24 | — | — | US | disclosed |
| US-9540327-B2 | Bis-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2017-01-10 | — | — | US | disclosed |
| US-9155733-B2 | Use of tris-quaternary ammonium salts as pain modulating agents | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2015-10-13 | — | — | US | disclosed |
| US-8940774-B2 | Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIV KENTUCKY RES FOUND (US) | 2015-01-27 | — | — | US | disclosed |
| US-20140371266-A1 | Mono Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIV KENTUCKY RES FOUND (US) | 2014-12-18 | — | — | US | disclosed |
| US-8846937-B2 | Mono quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-09-30 | — | — | US | disclosed |
| US-8703803-B2 | Tris-quaternary ammonium salts and methods for modulating neuronal nicotinic acetylcholine receptors | UNIV KENTUCKY RES FOUND (US) | 2014-04-22 | — | — | US | disclosed |
| US-20140080866-A1 | Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-03-20 | — | — | US | disclosed |
| US-8629163-B2 | Tetrakis-quaternary ammonium salts and methods for modulating neuronal nicotinic acteylcholine receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2014-01-14 | — | — | US | disclosed |
| US-20130030018-A1 | Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIV KENTUCKY RES FOUND (US) | 2013-01-31 | — | — | US | disclosed |
| US-20110105556-A1 | TRIS-QUARTERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2011-05-05 | — | — | US | disclosed |
| US-20100173937-A1 | USE OF TETRAKIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-07-08 | — | — | US | disclosed |
| US-20100120857-A1 | USE OF TRIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100113511-A1 | Mono Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2010-05-06 | — | — | US | disclosed |
| US-20090318503-A1 | BIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2009-12-24 | — | — | US | disclosed |
| US-20090143424-A1 | TETRAKIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACTEYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION (US) | 2009-06-04 | — | — | US | disclosed |
| WO-2007149392-A1 | MONO QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY (US) | 2007-12-27 | — | — | WO | disclosed |
| WO-2007094912-A2 | BIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY (US) | 2007-08-23 | — | — | WO | disclosed |
| WO-2007076112-A2 | TRIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | UNIVERSITY OF KENTUCKY (US) | 2007-07-05 | — | — | WO | disclosed |
| US-20030225142-A1 | Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225142-A1 | Chain-modified pyridino-N substituted nicotine compounds for use in the treatment of CNS pathologies | CHRNA4, CHRNA2, CHRNA5 | NPC1 3364/4885RAB9A 2610/4885MAPT 213/4885 |
| US-20130030018-A1 | Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | CHRNA10, CHRNA5, CHRNA2 | NPC1 1604/4885RAB9A 1337/4885MAPT 841/4885 |
| US-20090318503-A1 | BIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA2, CHRNA5, CHRNA4 | NPC1 1844/4885RAB9A 920/4885MAPT 640/4885 |
| US-20100113511-A1 | Mono Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | CHRNA2, CHRNA4, CHRNA5 | NPC1 1516/4885RAB9A 1858/4885MAPT 913/4885 |
| US-20140080866-A1 | Tris-Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | CHRNA4, CHRNA2, CHRNA10 | NPC1 2000/4885RAB9A 1262/4885MAPT 500/4885 |
| US-20110105556-A1 | TRIS-QUARTERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA5, CHRNA10, CHRNA4 | NPC1 1753/4885RAB9A 1556/4885MAPT 1141/4885 |
| US-20140371266-A1 | Mono Quaternary Ammonium Salts and Methods for Modulating Neuronal Nicotinic Acetylcholine Receptors | CHRNA2, CHRNA4, CHRNA5 | NPC1 1554/4885RAB9A 1883/4885MAPT 948/4885 |
| US-20100173937-A1 | USE OF TETRAKIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS | CACNA1I, TRPA1, KCNN3 | NPC1 3743/4885RAB9A 3311/4885MAPT 687/4885 |
| US-20100120857-A1 | USE OF TRIS-QUATERNARY AMMONIUM SALTS AS PAIN MODULATING AGENTS | OPRL1, CACNA1I, CACNA1G | NPC1 4446/4885RAB9A 1467/4885MAPT 1089/4885 |
| US-20090143424-A1 | TETRAKIS-QUATERNARY AMMONIUM SALTS AND METHODS FOR MODULATING NEURONAL NICOTINIC ACTEYLCHOLINE RECEPTORS | CHRNA3, CHRNA2, CHRNA4 | NPC1 1624/4885RAB9A 1791/4885MAPT 424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.