Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 12/20 | 0.46 |
| ▸ | PDE6C | P51160 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | PDE1A | P54750 | 3/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.42 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.42 |
| ▸ | PDE6D | O43924 | 1/20 | 0.42 |
| ▸ | PDE8A | O60658 | 1/20 | 0.42 |
| ▸ | PDE9A | O76083 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | PDE6A | P16499 | 1/20 | 0.42 |
| ▸ | PDE6G | P18545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6433453 | 0.85 | NPSR1 (0.43) | PDE5APDE6CNPSR1KMT2ALRRK2 | |
| SCHEMBL5085819 | 0.83 | PDE5A (0.65) | PDE5APDE6CPDE3BPDE3AKMT2A | |
| SCHEMBL3671938 | 0.82 | PDE5A (0.63) | PDE5APDE6CPDE3BPDE3APDE1A | |
| SCHEMBL7019558 | 0.79 | PARP1 (0.41) | PDE5APDE6CNPSR1PDE3BPDE3A | |
| Citric Acid SCHEMBL18919600 | 0.77 | PDE5A (0.68) | PDE5APDE6CPDE3BPDE3APDE1A | |
| SCHEMBL1872915 | 0.77 | PDE5A (0.58) | PDE5APDE6CPDE1APDE1BPDE1C | |
| SCHEMBL145682 | 0.77 | PDE5A (0.77) | PDE5APDE6CPDE3BPDE3APDE1A | |
| SCHEMBL29707546 | 0.77 | PDE5A (0.77) | PDE5APDE6CPDE3BPDE3APDE1A | |
| SCHEMBL14685941 | 0.77 | KDM4E (0.46) | PDE5APDE6CPDE1APDE2AABCC5 | |
| SCHEMBL14685954 | 0.76 | KDM4E (0.48) | PDE5APDE6CPDE3BPDE3APDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1276481-A2 | DAILY TREATMENT FOR ERECTILE DYSFUNCTION USING A PDE5 INHIBITOR | Lilly Icos LLC (US) | 2003-01-22 | — | — | EP | claimed |
| WO-2001080860-A2 | DAILY TREATMENT FOR ERECTILE DYSFUNCTION USING A PDE5 INHIBITOR | LILLY ICOS LLC (US) | 2001-11-01 | — | — | WO | claimed |
| EP-1276481-A2 | DAILY TREATMENT FOR ERECTILE DYSFUNCTION USING A PDE5 INHIBITOR | Lilly Icos LLC (US) | 2003-01-22 | — | — | EP | disclosed |
| WO-2001080860-A2 | DAILY TREATMENT FOR ERECTILE DYSFUNCTION USING A PDE5 INHIBITOR | LILLY ICOS LLC (US) | 2001-11-01 | — | — | WO | disclosed |