Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 4/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.34 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2921927 | 0.82 | GRIA1 (0.33) | GRIA1GRIA3PDE4DESR2 | |
| SCHEMBL3676538 | 0.81 | PTPRC (0.39) | GRIA1GRIA3PDE4DESR2MAOB | |
| SCHEMBL3681524 | 0.81 | CYP11B1 (0.45) | GRIA1GRIA3PDE4DESR2HIF1A | |
| SCHEMBL3665295 | 0.80 | ESR2 (0.36) | GRIA1GRIA3PDE4DESR2 | |
| SCHEMBL3667717 | 0.78 | PGR (0.44) | KDM4EMAOAMAOBALDH1A1 | |
| Water SCHEMBL4777578 | 0.77 | GRIA1 (0.56) | GRM5GRIA1GRIA3PDE4D | |
| SCHEMBL2918046 | 0.77 | GRIA1 (0.56) | GRM5GRIA1GRIA3PDE4D | |
| SCHEMBL6695571 | 0.77 | MEN1 (0.40) | PIM1KDM4EGRIA1GRIA3PDE4D | |
| SCHEMBL3668910 | 0.77 | GABRA1 (0.36) | KDM4EGRIA1GRIA3PDE4DESR2 | |
| SCHEMBL2763450 | 0.76 | GRIA2 (0.32) | GRIA1GRIA3PDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164487-A1 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR NEUROPATHIC PAIN | Eisai R&D Management Co., Ltd. (JP) | 2010-03-24 | — | — | EP | disclosed |
| WO-2009011411-A1 | AMPA RECEPTOR ANTAGONISTS AND ZONISAMIDE FOR NEUROPATHIC PAIN | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-01-22 | — | — | WO | disclosed |