Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRAS | P01112 | 14/20 | 0.70 |
| ▸ | ESR1 | P03372 | 13/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.70 |
| ▸ | TOP1 | P11387 | 2/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | POLB | P06746 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.33 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3680040 | 1.00 | HRAS (0.70) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL3454493 | 0.99 | KDM4E (0.70) | HRASESR1ESR2TOP1KDM4E | |
| Hydrochloric Acid SCHEMBL3455291 | 0.99 | KDM4E (0.70) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7501055 | 0.92 | HRAS (0.60) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7508683 | 0.92 | HRAS (0.60) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7508643 | 0.92 | HRAS (0.60) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7502387 | 0.92 | HRAS (0.60) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7503920 | 0.92 | HRAS (0.60) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7509566 | 0.92 | HRAS (0.60) | HRASESR1ESR2TOP1KDM4E | |
| SCHEMBL7119707 | 0.91 | HRAS (0.57) | HRASESR1ESR2TOP1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1889624-B1 | Combined therapy against tumors comprising substituted acryloyl distamycin derivatives, taxanes and/or antimetabolites | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-12-15 | — | — | EP | claimed |
| US-7030089-B2 | Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione | PHARMACIA ITALIA S.P.A. (IT) | 2006-04-18 | — | — | US | claimed |
| US-20030207794-A1 | Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2003-11-06 | — | — | US | claimed |
| EP-1280527-A2 | USE OF SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES IN THE TREATMENT OF TUMORS ASSOCIATED WITH HIGH LEVELS OF GLUTATHIONE | Pharmacia Italia S.p.A. (IT) | 2003-02-05 | — | — | EP | claimed |
| WO-2001085144-A2 | USE OF SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES IN THE TREATMENT OF TUMORS ASSOCIATED WITH HIGH LEVELS OF GLUTATHIONE | PHARMACIA ITALIA S.P.A. (IT) | 2001-11-15 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207794-A1 | Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione | GSTA1, GSTK1, GSTP1 | HRAS 18/4885ESR1 3956/4885ESR2 1378/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.