SCHEMBL3672708

SCHEMBL3672708

FC(F)(c1ccc(Br)cc1)C(F)(F)C(F)(F)c1ccc(Oc2ccc(C(F)(F)C(F)(F)C(F)(F)c3ccc(Br)cc3)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.48
SLC6A4 P31645 1/20 0.40
CA2 P00918 2/20 0.38
CA9 Q16790 2/20 0.38
CA1 P00915 1/20 0.38
CA5A P35218 1/20 0.38
THRB P10828 1/20 0.37
MAOA P21397 1/20 0.37
MAOB P27338 1/20 0.37
LTA4H P09960 3/20 0.36
ALDH1A1 P00352 2/20 0.35
NPC1 O15118 1/20 0.35
HPGD P15428 1/20 0.35
MAPK1 P28482 1/20 0.35
RAB9A P51151 1/20 0.35
PTGS2 P35354 2/20 0.35
MMP2 P08253 1/20 0.35
MMP9 P14780 1/20 0.35
MMP8 P22894 1/20 0.35
MMP14 P50281 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3674087 0.96 MAPT (0.48) MAPTSLC6A4CA2CA9CA1
SCHEMBL3676734 0.94 MAPT (0.47) MAPTSLC6A4CA2CA9CA1
SCHEMBL3682109 0.91 MAPT (0.52) MAPTSLC6A4CA2CA9CA1
SCHEMBL5239662 0.87 CA1 (0.46) CA2CA9CA1CA5AALDH1A1
SCHEMBL9262733 0.83 SLC6A4 (0.53) MAPTSLC6A4CA2CA9CA1
SCHEMBL3676966 0.82 CA1 (0.42) MAPTSLC6A4CA2CA9CA1
SCHEMBL19056952 0.82 CA1 (0.46) CA2CA9CA1CA5AALDH1A1
SCHEMBL19056950 0.80 CA1 (0.45) CA2CA9CA1CA5AALDH1A1
SCHEMBL4810839 0.79 ALDH1A1 (0.59) MAPTMAOAMAOBALDH1A1NPC1
SCHEMBL3679183 0.79 MAOA (0.48) MAPTSLC6A4MAOAMAOBLTA4H

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1329444-B1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORP (JP) 2010-05-05 EP disclosed
EP-1138712-B1 Polyarylene copolymers and proton-conductive membrane JSR CORP (JP) 2006-01-18 EP disclosed
US-6833426-B2 A proton-conductive membrane containing the sulfonic acid group-containing polyarylene (co)polymer JSR CORPORATION (JP) 2004-12-21 US disclosed
US-6812290-B2 FOR USE AS ELECTROLYTES JSR CORPORATION (JP) 2004-11-02 US disclosed
US-20030195301-A1 Polyarylene copolymers and proton-conductive membrane JSR CORPORATION (JP) 2003-10-16 US disclosed
US-20030173547-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORPORATION (JP) 2003-09-18 US disclosed
EP-1329444-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR Corporation (JP) 2003-07-23 EP disclosed
US-6555626-B2 Controlled amount of sulfonic acid groups; copolymer of an aromatic compound having a main chain containing electron withdrawing groups and aromatic compounds with no electron withdrawing groups; durability, strength, conductivity JSR CORPORATION (JP) 2003-04-29 US disclosed
US-20010037000-A1 Polyarylene copolymers and proton-conductive membrane JSR CORPORATION (JP) 2001-11-01 US disclosed
EP-1138712-A2 Polyarylene copolymers and proton-conductive membrane JSR Corporation (JP) 2001-10-04 EP disclosed