Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 2/20 | 0.34 |
| ▸ | EDNRA | P25101 | 2/20 | 0.34 |
| ▸ | KAT7 | O95251 | 1/20 | 0.34 |
| ▸ | KAT6B | Q8WYB5 | 1/20 | 0.34 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 3/20 | 0.34 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28001171 | 0.82 | KDM4E (0.50) | KDM4EMAPTCYP1A2ADORA2AMKNK1 | |
| SCHEMBL4949819 | 0.81 | CTSA (0.38) | KDM4EMAPTPARP1ALDH1A1TSHR | |
| SCHEMBL31678747 | 0.77 | PARP1 (0.43) | KDM4EMAPTPARP1ALDH1A1HPGD | |
| SCHEMBL16598176 | 0.75 | GPR52 (0.41) | KDM4EMAPTCYP1A2ADORA2AMKNK1 | |
| SCHEMBL30006999 | 0.75 | KDM4E (0.47) | KDM4EMAPTCYP1A2ALDH1A1CYP3A4 | |
| SCHEMBL28492022 | 0.75 | KDM4E (0.47) | KDM4EMAPTCYP1A2ALDH1A1CYP3A4 | |
| SCHEMBL16598113 | 0.74 | KDM4E (0.38) | KDM4EMAPTCYP1A2ADORA2AMKNK1 | |
| SCHEMBL2516051 | 0.74 | KDM4E (0.49) | KDM4EMAPTCYP1A2MKNK1MKNK2 | |
| SCHEMBL1503132 | 0.74 | KDM4E (0.49) | KDM4EMAPTCYP1A2MKNK1MKNK2 | |
| SCHEMBL4030545 | 0.74 | KDM4E (0.49) | KDM4EMAPTCYP1A2MKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2166846-A1 | INHIBITORS OF JANUS KINASES | Merck Sharp & Dohme Corp. (US) | 2010-03-31 | — | — | EP | claimed |
| WO-2008156726-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2008-12-24 | — | — | WO | claimed |