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Sugi Predict / Compounds / SCHEMBL367331

SCHEMBL367331

SCHEMBL367331

C=C(C)C(=O)OCCc1ccc(/N=N/C(C(C)=O)C(=O)Nc2ccc(C)cc2C)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SMN1; SMN2 Q16637 2/20 0.39
▸ L3MBTL1 Q9Y468 2/20 0.37
▸ KMT2A Q03164 2/20 0.36
▸ MEN1 O00255 1/20 0.36
▸ THRB P10828 1/20 0.36
▸ USP2 O75604 1/20 0.35
▸ HTT P42858 2/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ HDAC3 O15379 1/20 0.34
▸ HDAC4 P56524 1/20 0.34
▸ HDAC1 Q13547 1/20 0.34
▸ HDAC7 Q8WUI4 1/20 0.34
▸ HDAC2 Q92769 1/20 0.34
▸ HDAC10 Q969S8 1/20 0.34
▸ HDAC11 Q96DB2 1/20 0.34
▸ HDAC8 Q9BY41 1/20 0.34
▸ HDAC6 Q9UBN7 1/20 0.34
▸ HDAC9 Q9UKV0 1/20 0.34
▸ HDAC5 Q9UQL6 1/20 0.34
▸ LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL368573 0.89 SMN1; SMN2 (0.37) SMN1; SMN2KMT2AMEN1ALDH1A1HDAC1
SCHEMBL370938 0.82 SMN1; SMN2 (0.37) SMN1; SMN2KMT2AMEN1ALDH1A1HDAC1
SCHEMBL8930571 0.81 MAPT (0.45) L3MBTL1KMT2AMEN1THRBALDH1A1
SCHEMBL5823876 0.77 HTT (0.48) SMN1; SMN2L3MBTL1KMT2AMEN1THRB
SCHEMBL5823881 0.77 HTT (0.48) SMN1; SMN2L3MBTL1KMT2AMEN1THRB
SCHEMBL5823877 0.77 HTT (0.48) SMN1; SMN2L3MBTL1KMT2AMEN1THRB
SCHEMBL1299066 0.72 THRB (0.52) L3MBTL1KMT2AMEN1THRBALDH1A1
SCHEMBL1299063 0.72 THRB (0.52) L3MBTL1KMT2AMEN1THRBALDH1A1
SCHEMBL16324972 0.71 POLB (0.42) SMN1; SMN2KMT2AMEN1THRBHTT
SCHEMBL296203 0.71 CA1 (0.49) SMN1; SMN2L3MBTL1THRBHTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8188203-B2 Intraocular lens formed from a polymer of an unsaturated aryl monoazo dye containing a 2-pyrazolin-5-one, dimedone (5,5-dimethyl-1,3-cyclohexanedione), acetoacetamide, malonamide, barbituric acid or 1,3-propanedione residue; yellow light absorbers; block ultraviolet and/or violet-blue light transmission Abbott Medical Optics Inc. (US) 2012-05-29 — — US disclosed
US-8188203-B2 Intraocular lens formed from a polymer of an unsaturated aryl monoazo dye containing a 2-pyrazolin-5-one, dimedone (5,5-dimethyl-1,3-cyclohexanedione), acetoacetamide, malonamide, barbituric acid or 1,3-propanedione residue; yellow light absorbers; block ultraviolet and/or violet-blue light transmission Abbott Medical Optics Inc. (US) 2012-05-29 — — US disclosed
EP-2261696-B1 Copolymerizable azo compounds and articles containing them ABBOTT MEDICAL OPTICS INC (US) 2012-03-14 — — EP disclosed
EP-2261696-A1 Copolymerizable azo compounds and articles containing them Abbott Medical Optics Inc. (US) 2010-12-15 — — EP disclosed
US-20080182957-A1 Copolymerizable azo compounds and articles containing them Johnson & Johnson Surgical Vision, Inc. 2008-07-31 — — US disclosed
US-20080182957-A1 Copolymerizable azo compounds and articles containing them Johnson & Johnson Surgical Vision, Inc. 2008-07-31 — — US disclosed
US-7326423-B2 Copolymerizable azo compounds and articles containing them ADVANCED MEDICAL OPTICS, INC. (US) 2008-02-05 — — US disclosed
US-7326423-B2 Copolymerizable azo compounds and articles containing them ADVANCED MEDICAL OPTICS, INC. (US) 2008-02-05 — — US disclosed