Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL368573 | 0.89 | SMN1; SMN2 (0.37) | MAPTKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL370938 | 0.88 | SMN1; SMN2 (0.37) | MAPTKMT2AMEN1ALDH1A1HDAC1 | |
| SCHEMBL367331 | 0.81 | SMN1; SMN2 (0.39) | KMT2AMEN1ALDH1A1HDAC1HDAC6 | |
| SCHEMBL14532335 | 0.76 | CA12 (0.46) | MAPTKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL14535181 | 0.76 | CA12 (0.46) | MAPTKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL14501386 | 0.74 | TDP1 (0.43) | MAPTKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL14603427 | 0.74 | PPARA (0.50) | MAPTNPC1THRBRAB9AL3MBTL1 | |
| SCHEMBL14535113 | 0.71 | MAPT (0.58) | MAPTKMT2AMEN1TSHRALDH1A1 | |
| SCHEMBL28167692 | 0.70 | THRB (0.38) | MAPTTSHRALDH1A1LMNANPC1 | |
| SCHEMBL18637835 | 0.69 | LPAR1 (0.48) | MAPTKMT2AMEN1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188203-B2 | Intraocular lens formed from a polymer of an unsaturated aryl monoazo dye containing a 2-pyrazolin-5-one, dimedone (5,5-dimethyl-1,3-cyclohexanedione), acetoacetamide, malonamide, barbituric acid or 1,3-propanedione residue; yellow light absorbers; block ultraviolet and/or violet-blue light transmission | Abbott Medical Optics Inc. (US) | 2012-05-29 | — | — | US | disclosed |
| US-8188203-B2 | Intraocular lens formed from a polymer of an unsaturated aryl monoazo dye containing a 2-pyrazolin-5-one, dimedone (5,5-dimethyl-1,3-cyclohexanedione), acetoacetamide, malonamide, barbituric acid or 1,3-propanedione residue; yellow light absorbers; block ultraviolet and/or violet-blue light transmission | Abbott Medical Optics Inc. (US) | 2012-05-29 | — | — | US | disclosed |
| US-20080182957-A1 | Copolymerizable azo compounds and articles containing them | Johnson & Johnson Surgical Vision, Inc. | 2008-07-31 | — | — | US | disclosed |
| US-20080182957-A1 | Copolymerizable azo compounds and articles containing them | Johnson & Johnson Surgical Vision, Inc. | 2008-07-31 | — | — | US | disclosed |
| US-7326423-B2 | Copolymerizable azo compounds and articles containing them | ADVANCED MEDICAL OPTICS, INC. (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326423-B2 | Copolymerizable azo compounds and articles containing them | ADVANCED MEDICAL OPTICS, INC. (US) | 2008-02-05 | — | — | US | disclosed |