Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.60 |
| ▸ | TLR2 | O60603 | 2/20 | 0.56 |
| ▸ | MDM4 | O15151 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 5/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236374 | 1.00 | CASP3 (0.60) | CASP3TLR2MDM4TP53MDM2 | |
| SCHEMBL3378520 | 1.00 | CASP3 (0.60) | CASP3TLR2MDM4TP53MDM2 | |
| SCHEMBL29397986 | 1.00 | CASP3 (0.60) | CASP3TLR2MDM4TP53MDM2 | |
| SCHEMBL30802531 | 1.00 | CASP3 (0.60) | CASP3TLR2MDM4TP53MDM2 | |
| SCHEMBL31538719 | 0.90 | CASP3 (0.55) | CASP3TLR2MDM4TP53MDM2 | |
| SCHEMBL19542133 | 0.90 | CASP3 (0.55) | CASP3TLR2MDM4TP53MDM2 | |
| SCHEMBL7713104 | 0.88 | CASP3 (0.62) | CASP3TLR2MDM4TP53MDM2 | |
| SCHEMBL7726774 | 0.88 | CASP3 (0.62) | CASP3TLR2MDM4TP53MDM2 | |
| SCHEMBL120255 | 0.88 | TLR2 (0.59) | CASP3TLR2MDM4TP53MDM2 | |
| SCHEMBL7532853 | 0.88 | TLR2 (0.59) | CASP3TLR2MDM4TP53MDM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010116173-A1 | DEPSIPEPTIDES AND THEIR THERAPEUTIC USE | KARUS THERAPEUTICS LIMITED (GB) | 2010-10-14 | — | — | WO | disclosed |
| WO-2010116173-A1 | DEPSIPEPTIDES AND THEIR THERAPEUTIC USE | KARUS THERAPEUTICS LIMITED (GB) | 2010-10-14 | — | — | WO | disclosed |