SCHEMBL3673613

SCHEMBL3673613

O=C(Nc1ccc(Oc2cccc(NC(=O)c3ccc(Cl)cc3)c2)cc1)c1ccc(Cl)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.64
MEN1 O00255 3/20 0.64
HPSE Q9Y251 1/20 0.64
NR1H4 Q96RI1 1/20 0.63
PGR P06401 2/20 0.61
BRAF P15056 1/20 0.61
HDAC1 Q13547 1/20 0.61
ALDH1A1 P00352 3/20 0.61
PNLIP P16233 2/20 0.61
ALOX12 P18054 2/20 0.61
HTT P42858 2/20 0.61
LMNA P02545 1/20 0.61
MAPT P10636 1/20 0.61
NPC1 O15118 3/20 0.59
RAB9A P51151 3/20 0.59
TDP1 Q9NUW8 3/20 0.59
SMN1; SMN2 Q16637 2/20 0.59
TP53 P04637 1/20 0.59
PKM P14618 1/20 0.59
KCNQ3 O43525 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13192835 0.91 KCNK3 (0.62) KMT2AMEN1HPSENR1H4PGR
SCHEMBL18745408 0.89 HPSE (0.57) KMT2AMEN1HPSENR1H4PGR
SCHEMBL809338 0.88 KMT2A (0.69) KMT2AMEN1PGRBRAFHDAC1
SCHEMBL3678321 0.88 NPC1 (0.71) NR1H4PGRMAPTNPC1RAB9A
SCHEMBL3679912 0.86 HPSE (0.64) KMT2AMEN1HPSENR1H4PGR
SCHEMBL3677131 0.86 HPSE (0.64) KMT2AMEN1HPSENR1H4PGR
SCHEMBL27858304 0.84 NPC1 (0.75) KMT2AMEN1HPSENR1H4PGR
SCHEMBL17342684 0.84 ENPP1 (0.70) KMT2AMEN1PGRBRAFHDAC1
SCHEMBL15140882 0.84 HPSE (0.55) KMT2AMEN1HPSENR1H4ALDH1A1
SCHEMBL4250977 0.83 NPC1 (0.81) KMT2AALDH1A1MAPTNPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1329444-B1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORP (JP) 2010-05-05 EP disclosed
EP-1138712-B1 Polyarylene copolymers and proton-conductive membrane JSR CORP (JP) 2006-01-18 EP disclosed
US-6933068-B2 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA (JP) 2005-08-23 US disclosed
EP-1245554-B1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR CORP (JP) 2005-01-26 EP disclosed
US-6833426-B2 A proton-conductive membrane containing the sulfonic acid group-containing polyarylene (co)polymer JSR CORPORATION (JP) 2004-12-21 US disclosed
US-6812290-B2 FOR USE AS ELECTROLYTES JSR CORPORATION (JP) 2004-11-02 US disclosed
US-6794480-B2 POLYARYLENE-BASED COPOLYMER USEFUL AS PROTON-CONDUCTIVE MEMBRANE WHICH CAN BE USED AS ELECTRON FOR PRIMARY BATTERY, ELECTROLYTE FOR SECONDARY BATTERY, HIGH MOLECULAR SOLID ELECTROLYTE FOR FUEL CELL JSR CORPORATION (JP) 2004-09-21 US disclosed
US-20030195301-A1 Polyarylene copolymers and proton-conductive membrane JSR CORPORATION (JP) 2003-10-16 US disclosed
US-20030173547-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORPORATION (JP) 2003-09-18 US disclosed
EP-1329444-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR Corporation (JP) 2003-07-23 EP disclosed
US-6555626-B2 Controlled amount of sulfonic acid groups; copolymer of an aromatic compound having a main chain containing electron withdrawing groups and aromatic compounds with no electron withdrawing groups; durability, strength, conductivity JSR CORPORATION (JP) 2003-04-29 US disclosed
US-20020177656-A1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR CORPORATION (JP) 2002-11-28 US disclosed
US-20020172850-A1 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA, JSR CORPORATION 2002-11-21 US disclosed
EP-1245554-A1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR Corporation (JP) 2002-10-02 EP disclosed
US-20010037000-A1 Polyarylene copolymers and proton-conductive membrane JSR CORPORATION (JP) 2001-11-01 US disclosed
EP-1138712-A2 Polyarylene copolymers and proton-conductive membrane JSR Corporation (JP) 2001-10-04 EP disclosed