Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.44 |
| ▸ | CA9 | Q16790 | 10/20 | 0.44 |
| ▸ | CA1 | P00915 | 9/20 | 0.44 |
| ▸ | CA12 | O43570 | 7/20 | 0.44 |
| ▸ | CA7 | P43166 | 4/20 | 0.43 |
| ▸ | CA6 | P23280 | 3/20 | 0.43 |
| ▸ | CA5A | P35218 | 3/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673619 | 0.81 | CA1 (0.30) | CA2CA9CA1CA12CA7 | |
| SCHEMBL1080712 | 0.71 | CA2 (0.45) | CA2CA9CA1CA12CA7 | |
| SCHEMBL4087878 | 0.70 | KDM4E (0.41) | — | |
| SCHEMBL1094650 | 0.68 | CA2 (0.44) | CA2CA9CA1CA12CA7 | |
| SCHEMBL11208011 | 0.68 | CA2 (0.44) | CA2CA9CA1CA12CA7 | |
| SCHEMBL326634 | 0.68 | CA2 (0.44) | CA2CA9CA1CA12CA7 | |
| SCHEMBL7646065 | 0.67 | CA2 (0.43) | CA2CA9CA1CA12CA7 | |
| SCHEMBL3262642 | 0.66 | CA2 (0.53) | CA2CA9CA1CA12CA7 | |
| SCHEMBL202947 | 0.65 | CA2 (0.70) | CA2CA9CA1CA12CA7 | |
| SCHEMBL4937327 | 0.63 | CA2 (0.60) | CA2CA9CA1CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541588-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2013-09-24 | — | — | US | disclosed |
| EP-2176247-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | Amgen Inc. (US) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009009122-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | AMGEN INC. (US) | 2009-01-15 | — | — | WO | disclosed |