Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 2/20 | 0.30 |
| ▸ | CA4 | P22748 | 2/20 | 0.30 |
| ▸ | CA6 | P23280 | 2/20 | 0.30 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CA5A | P35218 | 1/20 | 0.30 |
| ▸ | CA7 | P43166 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.30 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673621 | 0.81 | CA2 (0.44) | CA1CA2CA4CA6CA12 | |
| SCHEMBL1080710 | 0.72 | CA2 (0.32) | CA1CA2CA12CA7CA9 | |
| SCHEMBL4087876 | 0.69 | ALDH1A1 (0.32) | — | |
| SCHEMBL5602626 | 0.58 | NOTUM (0.47) | CYP2C9 | |
| SCHEMBL6622889 | 0.56 | PDIA6 (0.39) | CA1CA2CA7 | |
| SCHEMBL4087878 | 0.55 | KDM4E (0.41) | — | |
| SCHEMBL2774927 | 0.53 | CCR2 (0.50) | CA1CA2CA4CA6CA12 | |
| SCHEMBL1080712 | 0.53 | CA2 (0.45) | CA1CA2CA4CA6CA12 | |
| SCHEMBL962913 | 0.52 | CA1 (0.53) | CA1CA2CA4CA6CA12 | |
| SCHEMBL789994 | 0.52 | PTGS1 (0.48) | CA1CA2CA12CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176247-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | Amgen Inc. (US) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009009122-A2 | DERIVATIVES OF UREA AND RELATED DIAMINES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR | AMGEN INC. (US) | 2009-01-15 | — | — | WO | disclosed |