Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 5/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11545332 | 0.86 | ALDH1A1 (0.47) | ALDH1A1CYP1A2CYP2C9CYP2C19ADRA2A | |
| SCHEMBL11546306 | 0.77 | ALDH1A1 (0.42) | ALDH1A1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL3684202 | 0.77 | ALDH1A1 (0.43) | ALDH1A1CYP1A2CYP2C9CYP2C19ADRA2A | |
| SCHEMBL12238420 | 0.75 | ALDH1A1 (0.50) | ALDH1A1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL1527193 | 0.75 | ALDH1A1 (0.50) | ALDH1A1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL10399086 | 0.75 | ALDH1A1 (0.50) | ALDH1A1CYP1A2CYP2C9CYP2C19ADRA2A | |
| SCHEMBL12238419 | 0.75 | ALDH1A1 (0.50) | ALDH1A1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL9014808 | 0.73 | ALDH1A1 (0.44) | ALDH1A1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL6055090 | 0.73 | ALDH1A1 (0.52) | ALDH1A1CYP1A2CYP2C9CYP2C19KMT2A | |
| SCHEMBL1155486 | 0.73 | CYP1A2 (0.56) | ALDH1A1CYP1A2CYP2C9CYP2C19KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168246-A1 | AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE | RICHELSON ELLIOTT | 2010-07-01 | — | — | US | disclosed |
| US-20080275272-A1 | AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE | RICHELSON ELLIOTT | 2008-11-06 | — | — | US | disclosed |
| US-20070197662-A1 | AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2007-08-23 | — | — | US | disclosed |
| US-7214826-B2 | Amine compounds and inhibiting neurotransmitter reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2007-05-08 | — | — | US | disclosed |
| EP-1414425-A4 | AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION (US) | 2007-04-11 | — | — | EP | disclosed |
| US-20050215647-A1 | Amine compounds and inhibiting neurotransmitter reuptake | Mayo Foundation for Medical Education and Research and Virginia Tech Intellectual Properties, Inc. | 2005-09-29 | — | — | US | disclosed |
| US-6914080-B2 | Amine compounds and inhibiting neurotransmitter reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2005-07-05 | — | — | US | disclosed |
| US-20040143022-A1 | Amine compounds and inhibiting neurotransmitter reuptake | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2004-07-22 | — | — | US | disclosed |
| EP-1414425-A1 | AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2004-05-06 | — | — | EP | disclosed |
| US-6700018-B2 | 3-HYDROXY-2-(2-NAPHTHYL)PENTYLAMINE DERIVATIVES | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH | 2004-03-02 | — | — | US | disclosed |
| US-20030027869-A1 | Amine compounds and inhibiting neurotransmitter reuptake | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. | 2003-02-06 | — | — | US | disclosed |
| WO-2003007929-A1 | AMINE COMPOUNDS AND INHIBITING NEUROTRANSMITTER REUPTAKE | MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH (US) | 2003-01-30 | — | — | WO | disclosed |