Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | MGAM | O43451 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28281125 | 0.73 | KDM4E (0.40) | KDM4EHPGDALDH1A1HSD17B10MAPK1 | |
| SCHEMBL198283 | 0.69 | CYP3A4 (0.44) | KDM4EHPGDALDH1A1HSD17B10MAPK1 | |
| SCHEMBL3402748 | 0.67 | TUBB4A (0.48) | KDM4EHPGDALDH1A1HSD17B10MAPK1 | |
| SCHEMBL3674074 | 0.66 | CA9 (0.50) | KDM4EHPGDALDH1A1CYP3A4MAPT | |
| SCHEMBL30701949 | 0.66 | CA9 (0.50) | KDM4EHPGDALDH1A1CYP3A4MAPT | |
| SCHEMBL8561465 | 0.66 | SMN1; SMN2 (0.47) | KDM4EHPGDALDH1A1HSD17B10MAPK1 | |
| SCHEMBL1402474 | 0.65 | MAPT (0.61) | KDM4EHPGDALDH1A1HSD17B10MAPK1 | |
| SCHEMBL3401767 | 0.65 | TUBB4A (0.50) | KDM4ECYP3A4MAPTMCL1GAA | |
| SCHEMBL30879595 | 0.64 | CYP1A2 (0.51) | KDM4EHPGDALDH1A1HSD17B10MAPK1 | |
| SCHEMBL27499528 | 0.64 | CYP1A2 (0.51) | KDM4EHPGDALDH1A1HSD17B10MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231573-A1 | GOSSYPOL AND APOGOSSYPOL DERIVATIVES, PREPARATION THEREOF AND USES THEREOF | Universite Du Maine (Le Mans) (FR) | 2010-09-29 | — | — | EP | disclosed |
| WO-2009080949-A1 | GOSSYPOL AND APOGOSSYPOL DERIVATIVES, PREPARATION THEREOF AND USES THEREOF | UNIVERSITE DU MAINE (LE MANS) (FR) | 2009-07-02 | — | — | WO | disclosed |