Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ACE | P12821 | 2/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL690215 | 1.00 | ATM (0.59) | ATMPIK3CDGAAALDH1A1ACE | |
| SCHEMBL689733 | 1.00 | ATM (0.59) | ATMPIK3CDGAAALDH1A1ACE | |
| SCHEMBL19080644 | 1.00 | ATM (0.59) | ATMPIK3CDGAAALDH1A1ACE | |
| SCHEMBL689912 | 1.00 | ATM (0.59) | ATMPIK3CDGAAALDH1A1ACE | |
| SCHEMBL1303907 | 1.00 | ATM (0.59) | ATMPIK3CDGAAALDH1A1ACE | |
| SCHEMBL7882438 | 1.00 | ATM (0.59) | ATMPIK3CDGAAALDH1A1ACE | |
| SCHEMBL8989612 | 1.00 | ATM (0.59) | ATMPIK3CDGAAALDH1A1ACE | |
| SCHEMBL589712 | 1.00 | ATM (0.59) | ATMPIK3CDGAAALDH1A1ACE | |
| Hydrochloric Acid SCHEMBL350474 | 0.98 | ATM (0.57) | ATMPIK3CDGAAALDH1A1ACE | |
| Hydrochloric Acid SCHEMBL2147938 | 0.98 | ATM (0.57) | ATMPIK3CDGAAALDH1A1ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080176923-A1 | Proline Derivatives Used as Pharmaceutical Active Ingredients for the Treatment of Tumors | SALAMA ZOSER B | 2008-07-24 | — | — | US | claimed |
| CN-1997365-A | Anticancer composition containing proline or its derivative and antitumor antibody | SALAMA ZOSER B (DE) | 2007-07-11 | — | — | CN | claimed |
| CN-1942438-A | Proline derivatives as pharmaceutical active ingredients in the treatment of tumors | SALAMA Z B (DE) | 2007-04-04 | — | — | CN | claimed |
| EP-1765328-A1 | ANTI-CANCER COMPOSITION COMPRISING PROLINE OR ITS DERIVATIVES AND AN ANTI-TUMOUR ANTIBODY | Salama, Zoser B. (DE) | 2007-03-28 | — | — | EP | claimed |
| CN-1282463-C | Chinese medicinal composition possessing liver calming, promoting blood flow and tranquilization and its preparation mathod | SHANGHAI TAIWEI INSUSTRIAL CO (CN) | 2006-11-01 | — | — | CN | claimed |
| EP-1711462-A1 | PROLINE DERIVATIVES USED AS PHARMACEUTICAL ACTIVE INGREDIENTS FOR THE TREATMENT OF TUMOURS | Salama, Zoser B. nat.rer.Dr. (DE) | 2006-10-18 | — | — | EP | claimed |
| WO-2005120495-A1 | ANTI-CANCER COMPOSITION COMPRISING PROLINE OR ITS DERIVATIVES AND AN ANTI-TUMOUR ANTIBODY | SALAMA ZOSER B (DE) | 2005-12-22 | — | — | WO | claimed |
| US-20050276810-A1 | Anti-cancer composition comprising proline or its derivatives and an anti-tumour antibody | SALAMA ZOSER B | 2005-12-15 | — | — | US | claimed |
| CN-1657070-A | Chinese medicinal composition possessing liver calming, promoting blood flow and tranquilization and its preparation mathod | SHANGHAI TAIWEI INSUSTRIAL CO (CN) | 2005-08-24 | — | — | CN | claimed |
| WO-2005058816-A1 | PROLINE DERIVATIVES USED AS PHARMACEUTICAL ACTIVE INGREDIENTS FOR THE TREATMENT OF TUMOURS | SALAMA ZOSER B (DE) | 2005-06-30 | — | — | WO | claimed |
| EP-0912172-B1 | COMBINATION OF CIS-4-HYDROXY-L-PROLINE AND N-METHYL-CIS-4-HYDROXY-L-PROLINE FOR USE AS A THERAPEUTIC AGENT, IN PARTICULAR IN CANCER TREATMENT | HOERRMANN WILHELM (DE) | 2000-09-06 | — | — | EP | claimed |
| US-6066665-A | Combination of cis-4-hydroxy-L-proline and N-methyl-cis-4-hydroxy-L-proline for use as a therapeutic agent, in particular in cancer treatment | HOERRMANN WILHELM (DE) | 2000-05-23 | — | — | US | claimed |
| US-20250295157-A1 | METHODS FOR THE IMPROVEMENT AND MAINTENANCE OF WEIGHT LOSS | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 2025-09-25 | — | — | US | disclosed |
| US-20250289840-A1 | RNA STABILIZING SUBSTANCES AND METHODS OF USE | TEAM MEDICAL, LLC | 2025-09-18 | — | — | US | disclosed |
| US-12349713-B2 | Methods for the improvement and maintenance of weight loss | SOCIETE DES PRODUITS NESTLE S.A. (CH) | 2025-07-08 | — | — | US | disclosed |
| CN-118633743-A | Lipid-lowering nutritional composition based on reduced carbohydrate and fat formation and method of preparation | 法尔玛国际健康管理有限公司 | 2024-09-13 | — | — | CN | disclosed |
| EP-0223850-B1 | MEDICINES WHICH CONTAIN DERIVATIVES OF PROLINE OR HYDROXYPROLINE | Hoerrmann, Wilhelm, Dr. (DE) | 1990-04-11 | — | — | EP | disclosed |
| EP-0308983-A2 | NMR imaging with Mn(II) coordination compositions | SALUTAR, INC. (US) | 1989-03-29 | — | — | EP | disclosed |
| EP-0223850-A1 | MEDICINES WHICH CONTAIN DERIVATIVES OF PROLINE OR HYDROXYPROLINE. | HOERMANN WILHELM | 1987-06-03 | — | — | EP | disclosed |
| WO-1986007053-A1 | MEDICINES WHICH CONTAIN DERIVATIVES OF PROLINE OR HYDROXYPROLINE | HOERRMANN WILHELM (DE) | 1986-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176923-A1 | Proline Derivatives Used as Pharmaceutical Active Ingredients for the Treatment of Tumors | PREP, PRAP1, VHL | ATM 3665/4885PIK3CD 2695/4885GAA 294/4885 |
| US-20250289840-A1 | RNA STABILIZING SUBSTANCES AND METHODS OF USE | SYNCRIP, SNRPA, RNASE1 | ATM 3816/4885PIK3CD 2095/4885GAA 209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.