Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 8/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | EED | O75530 | 1/20 | 0.31 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.31 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.30 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840070 | 0.99 | SCN9A (0.36) | SCN9ACYP11B1CYP11B2KCNH2CYP19A1 | |
| Ammonia Solution, Strong SCHEMBL3676946 | 0.80 | SCN9A (0.46) | SCN9AKCNH2CYP19A1SCN5A | |
| Ammonia Solution, Strong SCHEMBL3672627 | 0.80 | SCN9A (0.49) | SCN9ACYP11B1CYP11B2KCNH2CYP19A1 | |
| SCHEMBL839937 | 0.79 | SCN9A (0.47) | SCN9AKCNH2CYP19A1SCN5A | |
| SCHEMBL3674960 | 0.79 | CYP11B1 (0.33) | CYP11B1CYP11B2CYP19A1CCNCCDK8 | |
| SCHEMBL841717 | 0.78 | SCN9A (0.50) | SCN9ACYP11B1CYP11B2KCNH2CYP19A1 | |
| Ammonia Solution, Strong SCHEMBL3672811 | 0.77 | SCN9A (0.46) | SCN9AKCNH2SCN5AEEDSUZ12 | |
| Ammonia Solution, Strong SCHEMBL3673791 | 0.77 | PIM1 (0.35) | SCN9AKCNH2SCN5A | |
| SCHEMBL839850 | 0.75 | SCN9A (0.46) | SCN9AKCNH2SCN5AEEDSUZ12 | |
| SCHEMBL841714 | 0.75 | ROCK2 (0.37) | SCN9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |