Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | CCNC | P24863 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840070 | 0.80 | SCN9A (0.36) | CYP11B1CYP11B2CCNCCDK8GRM4 | |
| SCHEMBL3672628 | 0.79 | SCN9A (0.41) | CYP11B1CYP11B2CYP1A2MAOA | |
| Ammonia Solution, Strong SCHEMBL3674959 | 0.79 | SCN9A (0.35) | CYP11B1CYP11B2CCNCCDK8GRM4 | |
| SCHEMBL3672812 | 0.76 | KCNH2 (0.38) | DPP4 | |
| SCHEMBL3673793 | 0.76 | PIM1 (0.33) | CYP11B1CYP11B2DPP4 | |
| SCHEMBL3668938 | 0.73 | NPC1 (0.37) | DPP4 | |
| SCHEMBL3670227 | 0.73 | JAK3 (0.33) | DPP4 | |
| SCHEMBL3668903 | 0.71 | SCN9A (0.41) | DPP4 | |
| SCHEMBL3673795 | 0.71 | DHFR (0.33) | DPP4 | |
| SCHEMBL3673478 | 0.71 | DPP4 (0.33) | DPP4GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2158198-A2 | NOVEL N- (8HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | AstraZeneca AB (SE) | 2010-03-03 | — | — | EP | disclosed |
| WO-2008130320-A2 | NOVEL N- (8-HETEROARYLTETRAHYDRONAPHTALENE-2YL) OR N- (5- HETEROARYLCHROMANE-3-YL) CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |