Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3003392 | 0.85 | TSHR (0.41) | HSD11B1CYP2D6LMNACHRM2ADRA2A | |
| SCHEMBL3737750 | 0.85 | TSHR (0.41) | HSD11B1CYP2D6LMNACHRM2ADRA2A | |
| SCHEMBL1665969 | 0.79 | TSHR (0.39) | HSD11B1CYP2D6LMNACHRM2ADRA2A | |
| SCHEMBL1666429 | 0.79 | TSHR (0.39) | HSD11B1CYP2D6LMNACHRM2ADRA2A | |
| SCHEMBL2999311 | 0.77 | HSD11B1 (0.46) | HSD11B1KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL2999789 | 0.77 | HSD11B1 (0.46) | HSD11B1KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL3010667 | 0.77 | HSD11B1 (0.46) | HSD11B1KMT2AMAPTMEN1SMN1; SMN2 | |
| SCHEMBL1700728 | 0.76 | LMNA (0.39) | HSD11B1CYP2D6LMNACHRM2ADRA2A | |
| SCHEMBL1700434 | 0.76 | LMNA (0.39) | HSD11B1CYP2D6LMNACHRM2ADRA2A | |
| SCHEMBL1700436 | 0.76 | LMNA (0.39) | HSD11B1CYP2D6LMNACHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139861-A1 | BENZIMIDAZOLES WITH A HETERO SPIRO-DECANE RESIDUE AS NPY-Y5 ANTAGONISTS | Glaxo Group Limited (GB) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008129007-A1 | BENZIMIDAZOLES WITH A HETERO SPIRO-DECANE RESIDUE AS NPY-Y5 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |