Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | MGLL | Q99685 | 2/20 | 0.60 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | TNF | P01375 | 1/20 | 0.55 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.55 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.55 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.55 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | F10 | P00742 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4450492 | 0.89 | ENPP2 (0.56) | RAB9ANPC1MEN1KMT2AMGLL | |
| SCHEMBL4444734 | 0.89 | NR1H4 (0.69) | RAB9ANPC1MEN1KMT2ANR1H4 | |
| SCHEMBL5263392 | 0.86 | NPC1 (0.49) | RAB9ANPC1MEN1KMT2AMGLL | |
| SCHEMBL10599853 | 0.85 | MEN1 (0.79) | RAB9ANPC1MEN1KMT2ANR1H4 | |
| SCHEMBL3294745 | 0.85 | NPC1 (0.54) | RAB9ANPC1MEN1KMT2ANR1H4 | |
| SCHEMBL2750411 | 0.83 | SMN1; SMN2 (0.75) | RAB9ANPC1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3786463 | 0.82 | NQO2 (0.73) | RAB9ANPC1MEN1KMT2AMGLL | |
| SCHEMBL13298071 | 0.81 | MAOB (0.54) | MEN1KMT2ANR1H4LMNA | |
| SCHEMBL6204492 | 0.80 | NQO2 (0.55) | RAB9ANPC1MEN1KMT2AMGLL | |
| SCHEMBL5906609 | 0.79 | PPARG (0.65) | NR1H4MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170072-A1 | FARNESOID X RECEPTOR AGONISTS | GlaxoSmithKline LLC (US) | 2010-04-07 | — | — | EP | disclosed |
| WO-2008157270-A1 | FARNESOID X RECEPTOR AGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |