Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO2 | P16083 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.53 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.53 |
| ▸ | FYN | P06241 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3786463 | 0.84 | NQO2 (0.73) | NQO2CYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL8577619 | 0.82 | SMN1; SMN2 (0.70) | NQO2CYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL1749196 | 0.80 | MEN1 (0.59) | NQO2CYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL3675252 | 0.80 | RAB9A (0.65) | LMNACYP17A1CYP11B1CYP11B2MGLL | |
| SCHEMBL12999591 | 0.80 | NPC1 (0.69) | NQO2LMNACYP17A1CYP11B1CYP11B2 | |
| SCHEMBL27816274 | 0.79 | KMT2A (0.78) | LMNAMEN1KMT2ASMN1; SMN2MAPT | |
| SCHEMBL6251220 | 0.79 | LMNA (0.45) | LMNAGAAADORA3MGLLMEN1 | |
| SCHEMBL4654909 | 0.78 | ALDH1A1 (0.67) | NQO2CYP17A1CYP11B1CYP11B2HSD17B1 | |
| SCHEMBL969807 | 0.78 | RAB9A (0.65) | NQO2LMNACYP17A1CYP11B1CYP11B2 | |
| SCHEMBL14384612 | 0.78 | CNR1 (0.71) | CYP17A1CYP11B1CYP11B2HSD17B1HSD17B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597228-A2 | SUBSTITUTED N-ARYLHETEROCYCLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | Sanofi-Aventis Deutschland GmbH (DE) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004072025-A2 | SUBSTITUTED N-ARYLHETEROCYCLES, METHOD FOR PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-08-26 | — | — | WO | disclosed |