Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 19/20 | 1.00 |
| ▸ | KCNQ2 | O43526 | 19/20 | 1.00 |
| ▸ | KCNE1 | P15382 | 12/20 | 1.00 |
| ▸ | KCNQ1 | P51787 | 12/20 | 1.00 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.74 |
| ▸ | BACE1 | P56817 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5215833 | 0.90 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL14340100 | 0.90 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL5214671 | 0.88 | KCNQ3 (0.78) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL6180940 | 0.87 | KCNQ3 (0.78) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL6086341 | 0.87 | KCNQ3 (0.76) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL5216578 | 0.85 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL5215282 | 0.85 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 | |
| SCHEMBL14339872 | 0.85 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL5343768 | 0.85 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNE1KCNQ1KCNQ5 | |
| SCHEMBL5214418 | 0.85 | KCNQ3 (1.00) | KCNQ3KCNQ2KCNE1KCNQ1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240065988-A1 | COMBINED USE OF KETAMINE AND RETIGABINE (EZOGABINE) FOR THE TREATMENT OF PSYCHIATRIC DISORDERS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2024-02-29 | — | — | US | claimed |
| CN-121378039-A | Selective KCNQ channel opener and application thereof in pharmacy | 河北医科大学 | 2026-01-23 | — | — | CN | disclosed |
| US-12268683-B2 | Compounds and methods for synergistic activation of M channels | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2025-04-08 | — | — | US | disclosed |
| US-20240226054-A9 | AGENTS AND METHODS FOR PREVENTING AND TREATING SKELETAL MUSCLE DISEASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-07-11 | — | — | US | disclosed |
| US-20240131000-A1 | AGENTS AND METHODS FOR PREVENTING AND TREATING SKELETAL MUSCLE DISEASES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-04-25 | — | — | US | disclosed |
| US-20240065988-A1 | COMBINED USE OF KETAMINE AND RETIGABINE (EZOGABINE) FOR THE TREATMENT OF PSYCHIATRIC DISORDERS | YEDA RESEARCH AND DEVELOPMENT CO. LTD. (IL) | 2024-02-29 | — | — | US | disclosed |
| US-20230293594-A1 | METHODS OF TREATING NEUROPSYCHIATRIC DISORDERS | UNIV ROCHESTER (US) | 2023-09-21 | — | — | US | disclosed |
| CN-116763781-A | Triazole derivative and preparation method and application thereof | 华东师范大学 | 2023-09-19 | — | — | CN | disclosed |
| US-11690876-B2 | Methods of treating neuropsychiatric disorders | UNIVERSITY OF ROCHESTER (US) | 2023-07-04 | — | — | US | disclosed |
| US-20230015539-A1 | METHOD OF TREATMENT WITH KCNQ CHANNEL OPENERS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2023-01-19 | — | — | US | disclosed |
| US-6737422-B2 | VOLTAGE-DEPENDENT | ICAGEN, INC. | 2004-05-18 | — | — | US | disclosed |
| US-6605725-B2 | Treating a central or peripheral nervous system disorder or condition through modulation of a voltage-dependent potassium channel | ICAGEN, INC. | 2003-08-12 | — | — | US | disclosed |
| EP-1208085-A4 | BENZANILIDES AS POTASSIUM CHANNEL OPENERS | ICAGEN INC (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6495550-B2 | SUBSTITUTED BENZAMIDO-PYRIDINE DERIVATIVES FOR TREATMENT OF DISORDERS MEDIATED BY POTASSIUM CHANNELS | ICAGEN, INC. | 2002-12-17 | — | — | US | disclosed |
| US-20020091122-A1 | Benzanilides as potassium channel openers | ICAGEN, INC. (US) | 2002-07-11 | — | — | US | disclosed |
| EP-1208085-A2 | BENZANILIDES AS POTASSIUM CHANNEL OPENERS | Icagen, Inc. (US) | 2002-05-29 | — | — | EP | disclosed |
| US-20020052393-A1 | Benzanilides as potassium channel openers | ICAGEN, INC. (US) | 2002-05-02 | — | — | US | disclosed |
| US-6372767-B1 | NERVOUS SYSTEM DISORDERS WITH HETEROCYCLIC SUBSTITUTED BEMZANILIDES | ICAGEN, INC. | 2002-04-16 | — | — | US | disclosed |
| US-20010049444-A1 | Pyridine-substituted benzanilides as potassium ion channel openers | ICAGEN, INC. | 2001-12-06 | — | — | US | disclosed |
| WO-2001010380-A2 | BENZANILIDES AS POTASSIUM CHANNEL OPENERS | ICAGEN, INC. (US) | 2001-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020091122-A1 | Benzanilides as potassium channel openers | KCNJ2, KCNA3, KCNH2 | KCNQ3 13/4885KCNQ2 6/4885KCNE1 31/4885 |
| US-20020052393-A1 | Benzanilides as potassium channel openers | KCNJ2, KCNA3, KCNH2 | KCNQ3 13/4885KCNQ2 6/4885KCNE1 31/4885 |
| US-20010049444-A1 | Pyridine-substituted benzanilides as potassium ion channel openers | KCNJ2, KCNJ1, KCNN3 | KCNQ3 18/4885KCNQ2 12/4885KCNE1 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.