6-Benzylthioinosine

6-Benzylthioinosine

SCHEMBL3676029

OC[C@H]1O[C@@H](n2cnc3c(SCc4ccccc4)ncnc32)C(O)C1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ SLC29A1 Q99808 19/20 1.00
▸ STAT6 P42226 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
6-Benzylthioinosine SCHEMBL15427008 1.00 SLC29A1 (1.00) SLC29A1STAT6
6-Benzylthioinosine SCHEMBL7617372 1.00 SLC29A1 (1.00) SLC29A1STAT6
6-Benzylthioinosine SCHEMBL7617380 1.00 SLC29A1 (1.00) SLC29A1STAT6
SCHEMBL5044909 0.91 SLC29A1 (0.91) SLC29A1STAT6
SCHEMBL23323472 0.88 SLC29A1 (0.79) SLC29A1STAT6
SCHEMBL13688488 0.88 SLC29A1 (0.79) SLC29A1STAT6
SCHEMBL27427587 0.87 SLC29A1 (0.76) SLC29A1STAT6
SCHEMBL6760626 0.86 SLC29A1 (0.81) SLC29A1STAT6
Nitrobenzylmercaptopurine Ribonucleoside SCHEMBL1321676 0.86 SLC29A1 (1.00) SLC29A1STAT6
Nitrobenzylmercaptopurine Ribonucleoside SCHEMBL290702 0.86 SLC29A1 (1.00) SLC29A1STAT6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4662319-A2 PERSONALIZED CRISPR PROFILING FOR CANCER Integrate Bioscience LLC (US) 2025-12-17 — — EP disclosed
WO-2024168301-A2 PERSONALIZED CRISPR PROFILING FOR CANCER FUNCTION ONCOLOGY, INC. (US) 2024-08-15 — — WO disclosed
US-20240226234-A1 WNT5A PEPTIDES FOR THE TREATMENT OF ACUTE MYELOGENOUS LEUKEMIA WNTRESEARCH AB (SE) 2024-07-11 — — US disclosed
EP-4346873-A1 WNT5A PEPTIDES FOR THE TREATMENT OF ACUTE MYELOGENOUS LEUKEMIA Wntresearch AB (SE) 2024-04-10 — — EP disclosed
CN-117500517-A WNT5A peptides for treating acute myelogenous leukemia 温特研究公司 2024-02-02 — — CN disclosed
WO-2022253506-A1 WNT5A PEPTIDES FOR THE TREATMENT OF ACUTE MYELOGENOUS LEUKEMIA WNTRESEARCH AB (SE) 2022-12-08 — — WO disclosed
US-10300049-B2 Myeloid differentiation inducing agents CASE WESTERN RESERVE UNIVERSITY (US) 2019-05-28 — — US disclosed
US-20170000774-A1 MYELOID DIFFERENTIATION INDUCING AGENTS CASE WESTERN RESERVE UNIVERSITY 2017-01-05 — — US disclosed
US-9439894-B2 Myeloid differentiation inducing agents CASE WESTERN RESERVE UNIVERSITY (US) 2016-09-13 — — US disclosed
WO-2015042158-A1 MYELOID DIFFERENTIATION INDUCING AGENTS CASE WESTERN RESERVE UNIVERSITY (US) 2015-03-26 — — WO disclosed
US-8815827-B2 Myeloid differentiation inducing agents CASE WESTERN RESERVE UNIVERSITY (US) 2014-08-26 — — US disclosed
US-20140018383-A1 MYELOID DIFFERENTIATION INDUCING AGENTS CASE WESTERN RESERVE UNIVERSITY (US) 2014-01-16 — — US disclosed
US-20100267656-A1 MYELOID DIFFERENTIATION INDUCING AGENTS CASE WESTERN RESERVE UNIVERSITY 2010-10-21 — — US disclosed
US-20100179312-A1 CONVERTIBLE NUCLEOSIDE DERIVATIVES LAKSHMAN MAHESH K 2010-07-15 — — US disclosed
WO-2008154629-A1 MYELOID DIFFERENTIATION INDUCING AGENTS CASE WESTERN RESERVE UNIVERSITY (US) 2008-12-18 — — WO disclosed
EP-1612210-B1 New analogs of nitrobenzylthioinosine GRUENENTHAL GMBH (DE) 2007-09-26 — — EP disclosed
EP-1761534-A2 NEW ANALOGS OF NITROBENZYLTHIOINOSINE Grünenthal GmbH (DE) 2007-03-14 — — EP disclosed
WO-2006002846-A2 NEW ANALOGS OF NITROBENZYLTHIOINOSINE Grünenthal GmbH (DE) 2006-01-12 — — WO disclosed
EP-1612210-A1 New analogs of nitrobenzylthioinosine Grünenthal GmbH (DE) 2006-01-04 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100179312-A1 CONVERTIBLE NUCLEOSIDE DERIVATIVES PNP, NUDT1, NUDT14 SLC29A1 19/4885STAT6 4656/4885
US-20140018383-A1 MYELOID DIFFERENTIATION INDUCING AGENTS MYADM, MCL1, MYD88 SLC29A1 3318/4885STAT6 19/4885
US-20100267656-A1 MYELOID DIFFERENTIATION INDUCING AGENTS MYADM, MCL1, MYD88 SLC29A1 3096/4885STAT6 16/4885
US-20170000774-A1 MYELOID DIFFERENTIATION INDUCING AGENTS MYADM, MCL1, MYD88 SLC29A1 3318/4885STAT6 19/4885
US-10300049-B2 Myeloid differentiation inducing agents MYADM, MCL1, MYD88 SLC29A1 3318/4885STAT6 19/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback