Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.43 |
| ▸ | FEN1 | P39748 | 3/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | MC3R | P41968 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30521876 | 0.90 | BCAT2 (0.53) | BCAT2ALOX5APFEN1CSNK1A1TYRO3 | |
| SCHEMBL45147 | 0.90 | BCAT2 (0.53) | BCAT2ALOX5APFEN1CSNK1A1TYRO3 | |
| SCHEMBL31227852 | 0.90 | BCAT2 (0.53) | BCAT2ALOX5APFEN1CSNK1A1TYRO3 | |
| Trifluoroacetic Acid SCHEMBL30607684 | 0.80 | POLB (0.39) | ALOX5APFEN1MEN1POLBKMT2A | |
| SCHEMBL30776205 | 0.79 | KDM4C (0.48) | L3MBTL1KMT2ATSHRNPC1RAB9A | |
| SCHEMBL28532968 | 0.79 | KDM4C (0.48) | L3MBTL1KMT2ATSHRNPC1RAB9A | |
| SCHEMBL30776208 | 0.79 | KDM4C (0.48) | L3MBTL1KMT2ATSHRNPC1RAB9A | |
| SCHEMBL30227102 | 0.79 | KDM4C (0.48) | L3MBTL1KMT2ATSHRNPC1RAB9A | |
| SCHEMBL27870881 | 0.78 | HCRTR2 (0.42) | ALOX5APFEN1MEN1POLBKMT2A | |
| Trifluoroacetic Acid SCHEMBL31255509 | 0.78 | BCAT2 (0.79) | BCAT2L3MBTL1ALOX5APFEN1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170848-A1 | PYRAZINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF LUNG DISEASES | AstraZeneca AB (SE) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009001132-A1 | PYRAZINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF LUNG DISEASES | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |