Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | CASP1 | P29466 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 6/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.62 |
| ▸ | RELA | Q04206 | 1/20 | 0.62 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.55 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.52 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45148 | 0.91 | KMT2A (0.73) | TSHRALOX15CASP1NPSR1HSD17B10 | |
| SCHEMBL30533391 | 0.90 | KMT2A (0.71) | TSHRALOX15CASP1NPSR1HSD17B10 | |
| SCHEMBL29238994 | 0.90 | KMT2A (0.71) | TSHRALOX15CASP1NPSR1HSD17B10 | |
| SCHEMBL22410921 | 0.82 | NPC1 (0.70) | TSHRALOX15CASP1NPSR1HSD17B10 | |
| SCHEMBL6642201 | 0.80 | KMT2A (0.67) | TSHRALOX15CASP1NPSR1HSD17B10 | |
| Imidazole SCHEMBL19436376 | 0.80 | KMT2A (0.58) | TSHRALOX15CASP1NPSR1HSD17B10 | |
| SCHEMBL11033096 | 0.79 | RAB9A (0.70) | TSHRALOX15CASP1NPSR1HSD17B10 | |
| SCHEMBL4868622 | 0.79 | KMT2A (0.74) | TSHRALOX15CASP1NPSR1HSD17B10 | |
| SCHEMBL2832098 | 0.77 | NPC1 (0.72) | NPSR1KMT2ARAB9ANPC1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL28718945 | 0.77 | TSHR (0.45) | TSHRALOX15CASP1NPSR1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2170848-A1 | PYRAZINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF LUNG DISEASES | AstraZeneca AB (SE) | 2010-04-07 | — | — | EP | disclosed |
| WO-2009001132-A1 | PYRAZINONE DERIVATIVES AND THEIR USE IN THE TREATMENT OF LUNG DISEASES | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |