Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | CASP1 | P29466 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.61 |
| ▸ | RELA | Q04206 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45148 | 0.88 | KMT2A (0.73) | KMT2ASMN1; SMN2TSHRHSD17B10ALOX15 | |
| SCHEMBL29238994 | 0.87 | KMT2A (0.71) | KMT2ASMN1; SMN2TSHRHSD17B10ALOX15 | |
| SCHEMBL30533391 | 0.87 | KMT2A (0.71) | KMT2ASMN1; SMN2TSHRHSD17B10ALOX15 | |
| SCHEMBL6646471 | 0.85 | RAB9A (0.70) | KMT2ASMN1; SMN2LMNAHIF1ATSHR | |
| SCHEMBL31414959 | 0.85 | RAB9A (0.70) | KMT2ASMN1; SMN2LMNAHIF1ATSHR | |
| SCHEMBL3409741 | 0.83 | KMT2A (0.66) | KMT2ASMN1; SMN2LMNATSHRHSD17B10 | |
| SCHEMBL23015752 | 0.80 | RAB9A (0.67) | KMT2ASMN1; SMN2LMNAHIF1AHSD17B10 | |
| SCHEMBL23446461 | 0.80 | MAPK8 (0.62) | KMT2ASMN1; SMN2LMNAHIF1ANPC1 | |
| SCHEMBL18398740 | 0.80 | TSHR (0.66) | KMT2ASMN1; SMN2TSHRHSD17B10ALOX15 | |
| SCHEMBL23410523 | 0.80 | MAPK8 (0.62) | SMN1; SMN2LMNAHIF1AHSD17B10NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453831-A1 | 1H-PYRROLO(3,2-B)PYRIDINE-3-CARBOXYLIC ACID AMIDES | Neurogen Corporation (US) | 2004-09-08 | — | — | EP | claimed |
| WO-2003044018-A1 | 1H-PYRROLO[3,2-B]PYRIDINE-3-CARBOXYLIC ACID AMIDES | NEUROGEN CORPORATION (US) | 2003-05-30 | — | — | WO | claimed |
| WO-2025092884-A1 | METHOD FOR TREATING LEUKEMIA | 深圳市塔吉瑞生物医药有限公司 | 2025-05-08 | — | — | WO | disclosed |
| CN-109651359-B | Substituted nicotinamide compound, pharmaceutical composition and application thereof | 深圳市塔吉瑞生物医药有限公司 | 2021-06-22 | — | — | CN | disclosed |