Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 6/20 | 0.57 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 1/20 | 0.43 |
| ▸ | CCR8 | P51685 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5039401 | 0.77 | TGFBR1 (0.54) | TGFBR1CYP2A6MAPK14CCR1CCR8 | |
| SCHEMBL2922398 | 0.75 | PDE10A (0.52) | GAAPDE10AKDM4ENOTUM | |
| SCHEMBL11231230 | 0.72 | CCR1 (0.44) | TGFBR1CYP2A6MAPK14CCR1CCR8 | |
| SCHEMBL30772217 | 0.71 | TGFBR1 (0.54) | TGFBR1CYP2A6MAPK14CCR1CCR8 | |
| SCHEMBL647992 | 0.71 | MEN1 (0.68) | TGFBR1CYP2A6CCR1CCR8MAPT | |
| SCHEMBL29963679 | 0.71 | MEN1 (0.68) | TGFBR1CYP2A6CCR1CCR8MAPT | |
| SCHEMBL31663552 | 0.70 | TGFBR1 (0.53) | TGFBR1CYP2A6MAPK14CCR1CCR8 | |
| SCHEMBL11010732 | 0.70 | PDE4A (0.53) | GAAMAPTKDM4EJAK2JAK1 | |
| Bromide SCHEMBL15901554 | 0.69 | RAB9A (0.65) | TGFBR1CYP2A6CCR1CCR8MAPT | |
| SCHEMBL12594495 | 0.69 | MEN1 (0.64) | TGFBR1CYP2A6CCR1CCR8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2254577-A1 | AMPA RECEPTOR ANTAGONISTS FOR EPILEPSY, MENTAL DISORDERS OR DEFICITS IN SENSORY ORGAN | Eisai R&D Management Co., Ltd. (JP) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009082039-A1 | AMPA RECEPTOR ANTAGONISTS FOR EPILEPSY, MENTAL DISORDERS OR DEFICITS IN SENSORY ORGAN | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-07-02 | — | — | WO | disclosed |