Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rel-Ritodrine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 3/20 | 0.97 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 3/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 3/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 3/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 2/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 2/20 | 1.00 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 1.00 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.97 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.97 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.97 |
| ▸ | GALR3 | O60755 | 1/20 | 0.97 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.59 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.59 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ritodrine SCHEMBL3677545 | 1.00 | LMNA (1.00) | LMNASLC6A2OPRM1HIF1ASLC6A4 | |
| Ritodrine SCHEMBL3677547 | 1.00 | LMNA (1.00) | LMNASLC6A2OPRM1HIF1ASLC6A4 | |
| Ritodrine SCHEMBL18952960 | 1.00 | LMNA (1.00) | LMNASLC6A2OPRM1HIF1ASLC6A4 | |
| Ritodrine SCHEMBL122631 | 1.00 | LMNA (1.00) | LMNASLC6A2OPRM1HIF1ASLC6A4 | |
| Ritodrine SCHEMBL2587077 | 0.98 | LMNA (0.97) | LMNASLC6A2OPRM1HIF1ASLC6A4 | |
| Ritodrine SCHEMBL4430018 | 0.98 | ADRB2 (1.00) | LMNASLC6A2OPRM1HIF1ASLC6A4 | |
| Ritodrine SCHEMBL34194 | 0.98 | ADRB2 (1.00) | LMNASLC6A2OPRM1HIF1ASLC6A4 | |
| Ritodrine SCHEMBL29395182 | 0.98 | ADRB2 (1.00) | LMNASLC6A2OPRM1HIF1ASLC6A4 | |
| Ritodrine SCHEMBL16267904 | 0.98 | ADRB2 (1.00) | LMNASLC6A2OPRM1HIF1ASLC6A4 | |
| Rel-Ritodrine SCHEMBL12959065 | 0.98 | ADRB2 (1.00) | LMNASLC6A2OPRM1HIF1ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155180-B1 | DRUG COMBINATION AND ITS USE IN THE TREATMENT OF MUSCLE LOSS | ACACIA PHARMA LTD (GB) | 2016-07-13 | — | — | EP | disclosed |
| US-8653052-B2 | Drug combination and its use in the treatment of muscle loss | ACACIA PHARMA LIMITED (GB) | 2014-02-18 | — | — | US | disclosed |
| US-20100130456-A1 | Drug Combination and Its Use in the Treatment of Muscle Loss | ACACIA PHARMA LIMITED (GB) | 2010-05-27 | — | — | US | disclosed |
| EP-2155180-A2 | DRUG COMBINATION AND ITS USE IN THE TREATMENT OF MUSCLE LOSS | Acacia Pharma Limited (GB) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008129308-A2 | DRUG COMBINATION AND ITS USE IN THE TREATMENT OF MUSCLE LOSS | ACACIA PHARMA LIMITED (GB) | 2008-10-30 | — | — | WO | disclosed |