Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.41 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
| ▸ | HCK | P08631 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6175794 | 0.94 | IDO1 (0.44) | CYP11B1CYP11B2LTA4HIDO1EP300 | |
| SCHEMBL365975 | 0.86 | ABCB1 (0.48) | CYP11B1CYP11B2LTA4HIDO1EP300 | |
| SCHEMBL12596117 | 0.84 | HCK (0.46) | IDO1EP300KAT8CNR1CNR2 | |
| SCHEMBL1978977 | 0.81 | HCK (0.47) | CYP11B1CYP11B2IDO1EP300KAT8 | |
| SCHEMBL12320309 | 0.78 | GPR84 (0.39) | IDO1EP300KAT8CNR1CNR2 | |
| SCHEMBL17912810 | 0.77 | CNR1 (0.60) | CYP11B1CYP11B2IDO1CNR1CNR2 | |
| SCHEMBL2558223 | 0.76 | CNR1 (0.40) | IDO1EP300KAT8CNR1CNR2 | |
| SCHEMBL592706 | 0.75 | IDO1 (0.53) | IDO1EP300KAT8GPR84 | |
| SCHEMBL11687927 | 0.75 | IDO1 (0.58) | IDO1EP300KAT8CNR1CNR2 | |
| SCHEMBL10129715 | 0.75 | IDO1 (0.53) | IDO1EP300KAT8GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147104-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2012-03-14 | — | — | EP | disclosed |