Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCK | P08631 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | NOS3 | P29474 | 2/20 | 0.42 |
| ▸ | NOS1 | P29475 | 2/20 | 0.42 |
| ▸ | NOS2 | P35228 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31086650 | 0.87 | IDO1 (0.44) | HCKMAPK12MAPK14NOS3NOS1 | |
| SCHEMBL1979771 | 0.87 | IDO1 (0.44) | HCKMAPK12MAPK14NOS3NOS1 | |
| SCHEMBL367776 | 0.84 | CYP11B1 (0.48) | HCKMAPK12MAPK14IDO1GPR84 | |
| SCHEMBL12320309 | 0.83 | GPR84 (0.39) | HCKMAPK12MAPK14IDO1GPR84 | |
| SCHEMBL12634044 | 0.82 | CYP11B1 (0.47) | HCKMAPK12MAPK14GPR84 | |
| SCHEMBL2558223 | 0.81 | CNR1 (0.40) | HCKMAPK12MAPK14IDO1GPR84 | |
| SCHEMBL1979137 | 0.79 | NR3C2 (0.51) | HCKMAPK12MAPK14CNR1CNR2 | |
| SCHEMBL6175794 | 0.78 | IDO1 (0.44) | MAPK12MAPK14IDO1GPR84EP300 | |
| SCHEMBL12288408 | 0.78 | HCK (0.55) | HCKMAPK12MAPK14 | |
| SCHEMBL14289950 | 0.78 | NOS3 (0.43) | NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011070368-A1 | ANTIVIRAL USE OF UREA COMPOUNDS | RESPIVERT LIMITED (GB) | 2011-06-16 | — | — | WO | disclosed |
| WO-2011070369-A1 | INHIBITORS OF HEMOPOIETIC CELL KINASE (P59-HCK) AND THEIR USE IN THE TREATMENT OF INFLUENZA INFECTION | RESPIVERT LIMITED (GB) | 2011-06-16 | — | — | WO | disclosed |