Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 9/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL359675 | 0.78 | GRM4 (1.00) | GRM4MEN1KMT2APOLBHTT | |
| SCHEMBL367814 | 0.78 | GRM4 (1.00) | GRM4MEN1KMT2APOLBHTT | |
| SCHEMBL15060591 | 0.78 | GRM4 (1.00) | GRM4MEN1KMT2APOLBHTT | |
| SCHEMBL14698148 | 0.78 | GRM4 (1.00) | GRM4MEN1KMT2APOLBHTT | |
| SCHEMBL5519146 | 0.74 | RAB9A (0.61) | MEN1KMT2APOLBHTTRAB9A | |
| SCHEMBL17835239 | 0.73 | GRM4 (0.73) | GRM4MEN1KMT2APOLBHTT | |
| SCHEMBL2246735 | 0.71 | MEN1 (0.96) | GRM4MEN1KMT2AALDH1A1GAA | |
| SCHEMBL20277498 | 0.71 | GRM4 (0.83) | GRM4MEN1KMT2APOLBHTT | |
| SCHEMBL11531098 | 0.70 | ALDH1A1 (0.41) | MEN1KMT2APOLBHTTRAB9A | |
| SCHEMBL18154026 | 0.69 | MEN1 (0.86) | GRM4MEN1KMT2AHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2804870-A1 | NOVEL 2-AMINO-4,5,6,8-TETRAHYDROPYRAZOLO[3,4-b]THIAZOLO [4,5-d]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2014-11-26 | — | — | EP | disclosed |
| WO-2013107862-A1 | NOVEL 2-AMINO-4,5,6,8-TETRAHYDROPYRAZOLO[3,4-b]THIAZOLO [4,5-d]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2013-07-25 | — | — | WO | disclosed |
| EP-2592932-A2 | NOVEL TETRAHYDROPYRAZOLO[3,4-B]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2013-05-22 | — | — | EP | disclosed |
| WO-2012009001-A2 | NOVEL TETRAHYDROPYRAZOLO[3,4-B]AZEPINE DERIVATIVES AND THEIR USE AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA S.A. (CH) | 2012-01-19 | — | — | WO | disclosed |