Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.80 |
| ▸ | MAPT | P10636 | 4/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.80 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.80 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.80 |
| ▸ | THRB | P10828 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.72 |
| ▸ | MEN1 | O00255 | 2/20 | 0.72 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.72 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.72 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MMP2 | P08253 | 3/20 | 0.50 |
| ▸ | MMP3 | P08254 | 3/20 | 0.50 |
| ▸ | MMP9 | P14780 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL728170 | 0.94 | MAPT (0.71) | ALDH1A1MAPTLMNANPSR1HSP90AA1 | |
| SCHEMBL728174 | 0.94 | MAPT (0.71) | ALDH1A1MAPTLMNANPSR1HSP90AA1 | |
| SCHEMBL225482 | 0.93 | ALDH1A1 (0.86) | ALDH1A1MAPTLMNANPSR1HSP90AA1 | |
| SCHEMBL726525 | 0.93 | KMT2A (0.76) | ALDH1A1MAPTLMNANPSR1HSP90AA1 | |
| SCHEMBL727031 | 0.93 | ALDH1A1 (0.86) | ALDH1A1MAPTLMNANPSR1HSP90AA1 | |
| SCHEMBL726709 | 0.89 | ALDH1A1 (0.70) | ALDH1A1MAPTLMNANPSR1HSP90AA1 | |
| SCHEMBL225008 | 0.89 | ALDH1A1 (1.00) | ALDH1A1MAPTLMNANPSR1HSP90AA1 | |
| SCHEMBL728190 | 0.89 | ALDH1A1 (0.70) | ALDH1A1MAPTLMNANPSR1HSP90AA1 | |
| SCHEMBL230158 | 0.87 | ALDH1A1 (0.80) | ALDH1A1MAPTLMNANPSR1HSP90AA1 | |
| SCHEMBL728416 | 0.86 | ALDH1A1 (0.62) | ALDH1A1MAPTLMNANPSR1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727977-B2 | Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-06-01 | — | — | US | disclosed |
| US-7727977-B2 | Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-06-01 | — | — | US | disclosed |
| US-7727977-B2 | Kynurenine 3-hydroxylase inhibitors for the treatment of diabetes | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-06-01 | — | — | US | disclosed |