Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.80 |
| ▸ | MAPT | P10636 | 5/20 | 0.80 |
| ▸ | HTT | P42858 | 2/20 | 0.80 |
| ▸ | POLB | P06746 | 2/20 | 0.80 |
| ▸ | RECQL | P46063 | 1/20 | 0.80 |
| ▸ | LMNA | P02545 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.58 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | PTGES | O14684 | 3/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.46 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11933966 | 0.89 | ALDH1A1 (1.00) | ALDH1A1MAPTHTTPOLBRECQL | |
| SCHEMBL726709 | 0.88 | ALDH1A1 (0.70) | ALDH1A1MAPTHTTPOLBRECQL | |
| SCHEMBL728190 | 0.88 | ALDH1A1 (0.70) | ALDH1A1MAPTHTTPOLBRECQL | |
| SCHEMBL3678664 | 0.87 | ALDH1A1 (0.80) | ALDH1A1MAPTHTTPOLBRECQL | |
| SCHEMBL229843 | 0.83 | ALDH1A1 (0.70) | ALDH1A1MAPTHTTPOLBRECQL | |
| SCHEMBL727031 | 0.83 | ALDH1A1 (0.86) | ALDH1A1MAPTHTTPOLBRECQL | |
| SCHEMBL225482 | 0.83 | ALDH1A1 (0.86) | ALDH1A1MAPTHTTPOLBRECQL | |
| SCHEMBL728170 | 0.82 | MAPT (0.71) | ALDH1A1MAPTHTTPOLBRECQL | |
| SCHEMBL728174 | 0.82 | MAPT (0.71) | ALDH1A1MAPTHTTPOLBRECQL | |
| SCHEMBL2166193 | 0.81 | ALDH1A1 (0.63) | ALDH1A1MAPTHTTPOLBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8329149-B2 | Topical lightening composition and uses thereof | AVON PRODUCTS, INC. (US) | 2012-12-11 | — | — | US | claimed |
| EP-2521558-A1 | TOPICAL LIGHTENING COMPOSITION AND USES THEREOF | Avon Products, Inc. (US) | 2012-11-14 | — | — | EP | claimed |
| US-20120003168-A1 | Topical Lightening Composition and Uses Thereof | AVON PRODUCTS, INC. (US) | 2012-01-05 | — | — | US | claimed |
| EP-2659004-B1 | MODULATION OF DYNEIN IN SKIN | AVON PROD INC (US) | 2017-08-30 | — | — | EP | disclosed |
| EP-2889384-B1 | Method for identifying active agents for improving the aesthetic appearance of human skin | AVON PROD INC (US) | 2016-09-28 | — | — | EP | disclosed |
| EP-2889384-A1 | Modulation of dynein in skin | Avon Products, Inc. (US) | 2015-07-01 | — | — | EP | disclosed |
| US-8329149-B2 | Topical lightening composition and uses thereof | AVON PRODUCTS, INC. (US) | 2012-12-11 | — | — | US | disclosed |
| WO-2012091832-A2 | MODULATION OF DYNEIN IN SKIN | AVON PRODUCTS, INC. (US) | 2012-07-05 | — | — | WO | disclosed |
| US-20120171133-A1 | Modulation of Dynein in Skin | AVON PRODUCTS, INC. (US) | 2012-07-05 | — | — | US | disclosed |
| US-20120171133-A1 | Modulation of Dynein in Skin | AVON PRODUCTS, INC. (US) | 2012-07-05 | — | — | US | disclosed |
| US-20120003168-A1 | Topical Lightening Composition and Uses Thereof | AVON PRODUCTS, INC. (US) | 2012-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120003168-A1 | Topical Lightening Composition and Uses Thereof | TYR, AOC3, TH | ALDH1A1 129/4885MAPT 793/4885HTT 2137/4885 |
| US-20120171133-A1 | Modulation of Dynein in Skin | DYNLL2, DYNLL1, DYNC1H1 | ALDH1A1 814/4885MAPT 1078/4885HTT 1740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.