Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | FKBP1A | P62942 | 8/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12988518 | 0.84 | FKBP1A (0.71) | TSHRL3MBTL1FKBP1AALDH1A1KDM4E | |
| SCHEMBL368798 | 0.77 | TSHR (0.54) | TSHRL3MBTL1FKBP1AALDH1A1KDM4E | |
| SCHEMBL6259280 | 0.77 | ALDH1A1 (0.67) | TSHRFKBP1AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL8320871 | 0.75 | ALDH1A1 (0.79) | FKBP1AALDH1A1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL31428775 | 0.75 | FKBP1A (0.69) | TSHRL3MBTL1FKBP1AALDH1A1KDM4E | |
| SCHEMBL6631915 | 0.75 | FKBP1A (0.69) | TSHRL3MBTL1FKBP1AALDH1A1KDM4E | |
| SCHEMBL12169303 | 0.75 | FKBP1A (0.69) | TSHRL3MBTL1FKBP1AALDH1A1KDM4E | |
| SCHEMBL370543 | 0.75 | CNR1 (0.59) | TSHRKDM4EKMT2APOLBRAB9A | |
| SCHEMBL4387896 | 0.74 | ALDH1A1 (0.58) | TSHRL3MBTL1FKBP1AALDH1A1KDM4E | |
| SCHEMBL7316803 | 0.74 | FKBP1A (0.67) | TSHRL3MBTL1FKBP1AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1147104-B1 | AROMATIC HETEROCYCLIC COMPOUNDS AS ANTIINFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2012-03-14 | — | — | EP | disclosed |