Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 5/20 | 0.78 |
| ▸ | RARG | P13631 | 5/20 | 0.78 |
| ▸ | RARA | P10276 | 4/20 | 0.78 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.52 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | PLAU | P00749 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PLAT | P00750 | 2/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | WDR5 | P61964 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.43 |
| ▸ | GOT1 | P17174 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30301169 | 0.88 | RARB (1.00) | RARBRARGRARAKMT2AWDR5 | |
| SCHEMBL980501 | 0.88 | RARB (1.00) | RARBRARGRARAKMT2AWDR5 | |
| SCHEMBL5027170 | 0.85 | MAPT (0.58) | RARBRARGRARAMAPTKMT2A | |
| SCHEMBL13900228 | 0.82 | CYP11B1 (0.69) | CYP11B1CYP11B2CYP19A1MAPTPLAU | |
| SCHEMBL12761561 | 0.82 | RARA (0.53) | RARBRARGRARAMAPTKMT2A | |
| SCHEMBL3673470 | 0.81 | RARA (0.54) | RARBRARGRARACYP11B1CYP11B2 | |
| SCHEMBL5606006 | 0.78 | CA1 (0.65) | CYP11B1CYP11B2CYP19A1MAPTPLAU | |
| SCHEMBL30698055 | 0.78 | CA1 (0.65) | CYP11B1CYP11B2CYP19A1MAPTPLAU | |
| SCHEMBL13980189 | 0.78 | RARB (0.62) | RARBRARGRARAPLAUWDR5 | |
| SCHEMBL10352726 | 0.77 | RARA (0.61) | RARBRARGRARAMAPTWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0199636-B1 | BENZONAPHTHALENIC DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN PHARMACY AND COSMETICS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. Groupement d'Intérêt Economique dit: (FR) | 1989-02-08 | — | — | EP | claimed |
| US-20100168241-A1 | TREATMENT OF ACNE DISEASE STATES, NOTABLY ACNE VULGARIS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-07-01 | — | — | US | disclosed |
| EP-2152259-A1 | USE OF A NAPHTOIC ACID DERIVATIVE IN COMBINATION WITH RED AND/OR BLUE LIGHT FOR TREATING ACNE VULGARIS | Galderma Research & Development (FR) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008135548-A1 | USE OF A NAPHTOIC ACID DERIVATIVE IN COMBINATION WITH RED AND/OR BLUE LIGHT FOR TREATING ACNE VULGARIS | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168241-A1 | TREATMENT OF ACNE DISEASE STATES, NOTABLY ACNE VULGARIS | RARA, RARB, RARG | RARB 2/4885RARG 3/4885RARA 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.