Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.65 |
| ▸ | CA2 | P00918 | 1/20 | 0.65 |
| ▸ | PLAU | P00749 | 9/20 | 0.62 |
| ▸ | PLAT | P00750 | 4/20 | 0.62 |
| ▸ | PLG | P00747 | 2/20 | 0.62 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.61 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30698055 | 1.00 | CA1 (0.65) | CA1CA2PLAUPLATPLG | |
| SCHEMBL13900228 | 0.91 | CYP11B1 (0.69) | CA1CA2PLAUPLATPLG | |
| SCHEMBL15897010 | 0.90 | CYP11B1 (0.69) | CA1CA2PLAUPLATPLG | |
| SCHEMBL2112531 | 0.87 | CA12 (0.61) | CA1CA2PLAUPLATPLG | |
| SCHEMBL2311608 | 0.87 | CYP19A1 (0.69) | CA1CA2PLAUPLATPLG | |
| SCHEMBL1856468 | 0.86 | KDM4E (0.70) | CA1CA2PLAUPLATPLG | |
| SCHEMBL16604876 | 0.86 | CA1 (0.88) | CA1CA2KMT2AKDM4EMEN1 | |
| SCHEMBL269558 | 0.86 | CA1 (0.88) | CA1CA2KMT2AKDM4EMEN1 | |
| SCHEMBL5224416 | 0.85 | APP (0.56) | CA1CA2PLAUPLATPLG | |
| SCHEMBL13486839 | 0.85 | CYP1A2 (0.60) | CA1CA2PLAUPLATPLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117700298-A | Preparation method of hydroxyl adapalene | 湖北广济药业股份有限公司 | 2024-03-15 | — | — | CN | claimed |
| CN-111333496-B | Preparation method of adapalene | 武汉诺安药业有限公司 | 2023-10-13 | — | — | CN | claimed |
| EP-0358574-B1 | PROCESS FOR THE PREPARATION OF ADAMANTANE-1 DERIVATIVES | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA - CIRD GALDERMA (FR) | 1993-02-17 | — | — | EP | claimed |
| CN-117700298-A | Preparation method of hydroxyl adapalene | 湖北广济药业股份有限公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-117700298-A | Preparation method of hydroxyl adapalene | 湖北广济药业股份有限公司 | 2024-03-15 | — | — | CN | disclosed |
| CN-111333496-B | Preparation method of adapalene | 武汉诺安药业有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-111333496-B | Preparation method of adapalene | 武汉诺安药业有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-111333496-A | Preparation method of adapalene | 武汉诺安药业有限公司 | 2020-06-26 | — | — | CN | disclosed |
| WO-2007125542-A2 | A PROCESS FOR PREPARATION OF ADAPALENE | USV LIMITED (IN) | 2007-11-08 | — | — | WO | disclosed |
| US-5015758-A | Process for the preparation of 1-adamantane derivatives | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD) (FR) | 1991-05-14 | — | — | US | disclosed |