Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.76 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.52 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 6/20 | 0.52 |
| ▸ | RXRB | P28702 | 6/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RXRG | P48443 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22480788 | 0.86 | MRGPRX4 (1.00) | MRGPRX4NR4A2RAB9ASMN1; SMN2 | |
| SCHEMBL6993654 | 0.83 | MRGPRX4 (0.70) | MRGPRX4NPC1RAB9ACYP3A4F2 | |
| SCHEMBL10236856 | 0.81 | MRGPRX4 (0.55) | MRGPRX4NPC1RAB9ASMN1; SMN2MAPT | |
| SCHEMBL1412056 | 0.79 | ALOX5 (0.67) | MRGPRX4NPC1RAB9ACYP3A4F2 | |
| SCHEMBL18906034 | 0.78 | NR4A2 (0.72) | NR4A2NR4A1NR4A3RXRARXRB | |
| SCHEMBL18546031 | 0.77 | MRGPRX4 (0.69) | MRGPRX4NR4A2NR4A1NR4A3NPC1 | |
| SCHEMBL16742694 | 0.77 | PTPN7 (0.66) | MRGPRX4POLBMAPTTSHRCYP26A1 | |
| SCHEMBL24124842 | 0.77 | RAB9A (0.65) | MRGPRX4NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29488886 | 0.76 | MRGPRX4 (0.56) | MRGPRX4CYP3A4 | |
| SCHEMBL1403704 | 0.76 | MRGPRX4 (0.56) | MRGPRX4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9102621-B2 | Acyl sulfonamide compounds | PFIZER LIMITED (GB) | 2015-08-11 | — | — | US | disclosed |
| EP-2593431-B1 | N-SULFONYLBENZAMIDES AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | PFIZER LTD (GB) | 2014-11-19 | — | — | EP | disclosed |
| EP-2593431-A2 | CHEMICAL COMPOUNDS | Pfizer Limited (GB) | 2013-05-22 | — | — | EP | disclosed |
| US-20130109708-A1 | Chemical Compounds | PFIZER LIMITED (GB) | 2013-05-02 | — | — | US | disclosed |
| WO-2012007869-A2 | CHEMICAL COMPOUNDS | PFIZER LIMITED (GB) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109708-A1 | Chemical Compounds | SCN1A, SCN1B, SCN7A | MRGPRX4 761/4885NR4A2 1933/4885NR4A1 1197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.