Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LSS | P48449 | 2/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3671618 | 0.91 | KDM4E (0.43) | KDM4ELMNAPOLBALDH1A1GAA | |
| SCHEMBL3682282 | 0.91 | KDM4E (0.53) | KDM4ELMNAPOLBALDH1A1KMT2A | |
| SCHEMBL9360025 | 0.87 | KDM4E (0.53) | KDM4ELMNAALDH1A1GAAKMT2A | |
| SCHEMBL9553332 | 0.85 | KDM4E (0.47) | KDM4ELMNAPOLBALDH1A1KMT2A | |
| SCHEMBL9364402 | 0.83 | LSS (0.59) | KDM4ELMNAPPARAALDH1A1GAA | |
| SCHEMBL8045891 | 0.80 | KDM4E (0.48) | KDM4ELMNAALDH1A1GAAKMT2A | |
| SCHEMBL9553073 | 0.79 | PPARA (0.51) | KDM4ELMNAPOLBPPARAPPARG | |
| SCHEMBL8046599 | 0.79 | PPARA (0.51) | KDM4ELMNAPOLBPPARAPPARG | |
| SCHEMBL3679260 | 0.78 | LSS (0.71) | KMT2ALSSMEN1 | |
| SCHEMBL8035731 | 0.78 | KDM4E (0.47) | KDM4ELMNAALDH1A1KMT2ALSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636367-B1 | Use of phenylalkylamines for producing cholesterol lowering agents | HOFFMANN LA ROCHE (CH) | 2000-03-29 | — | — | EP | claimed |
| EP-0410359-B1 | Substituted aminoalkoxy-benzene-derivatives | HOFFMANN LA ROCHE (CH) | 1994-01-26 | — | — | EP | claimed |
| JP-7053479-A | — | — | None | — | — | JP | disclosed |
| US-20100092479-A1 | Compositions and methods for treatment of viral diseases | COMBINATORX (SINGAPORE) PTE. LTD. (SG) | 2010-04-15 | — | — | US | disclosed |
| WO-2010021681-A2 | COMPOSITIONS AND METHODS FOR TREATMENT OF VIRAL DISEASES | COMBINATORX (SINGAPORE) PTE. LTD. (SG) | 2010-02-25 | — | — | WO | disclosed |
| US-5637771-A | Compound useful for lowering cholesterol | HOFFMANN-LA ROCHE INC. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5574071-A | ADMINISTERING PHENYLALKYLAMINO KETONES | HOFFMANN-LA ROCHE INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5495048-A | ANTICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| JP-H0753479-A | USE OF PHENALKYL AMINE | F HOFFMANN LA ROCHE AG | 1995-02-28 | — | — | JP | disclosed |
| US-5214046-A | Synergistic mixtures, inhibitors of sterol biosynthesis | HOFFMANN-LA ROCHE INC. (US) | 1993-05-25 | — | — | US | disclosed |
| US-5106878-A | Synergistic effects with other fungicides | HOFFMANN-LA ROCHE INC. (US) | 1992-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100092479-A1 | Compositions and methods for treatment of viral diseases | HAVCR2, RNASE1, EIF2AK2 | KDM4E 731/4885LMNA 340/4885POLB 219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.