Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9553073 | 1.00 | PPARA (0.51) | PPARAPPARGPPARDTHRATHRB | |
| SCHEMBL8045645 | 0.89 | KDM4E (0.50) | PPARDTHRATHRBHPGDKDM4E | |
| SCHEMBL8902445 | 0.88 | THRA (0.46) | PPARAPPARGPPARDTHRATHRB | |
| SCHEMBL9365209 | 0.85 | KDM4E (0.61) | PPARAPPARGPPARDTHRATHRB | |
| SCHEMBL9364450 | 0.84 | CYP1A2 (0.49) | PPARATHRATHRBMRGPRX4HPGD | |
| SCHEMBL9162800 | 0.83 | PLAU (0.50) | PPARAPPARGPPARDMRGPRX4HPGD | |
| SCHEMBL25780651 | 0.82 | THRA (0.50) | THRATHRBMRGPRX4KDM4ETDP1 | |
| SCHEMBL25781022 | 0.82 | THRA (0.50) | THRATHRBMRGPRX4KDM4ETDP1 | |
| SCHEMBL9360180 | 0.81 | MAPT (0.52) | THRATHRBMRGPRX4HPGDTDP1 | |
| SCHEMBL9428385 | 0.80 | ACHE (0.49) | PPARATHRATHRBMRGPRX4HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-7053479-A | — | — | None | — | — | JP | disclosed |
| EP-0994866-A1 | 5-(3-PHENYL-3-OXO-PROPYL)-1H-TETRAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.p.A. (IT) | 2000-04-26 | — | — | EP | disclosed |
| EP-0636367-B1 | Use of phenylalkylamines for producing cholesterol lowering agents | HOFFMANN LA ROCHE (CH) | 2000-03-29 | — | — | EP | disclosed |
| WO-1999002506-A1 | 5-(3-PHENYL-3-OXO-PROPYL)-1H-TETRAZOLE DERIVATIVES | PHARMACIA & UPJOHN S.P.A. (IT) | 1999-01-21 | — | — | WO | disclosed |
| US-5637771-A | Compound useful for lowering cholesterol | HOFFMANN-LA ROCHE INC. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5574071-A | ADMINISTERING PHENYLALKYLAMINO KETONES | HOFFMANN-LA ROCHE INC. (US) | 1996-11-12 | — | — | US | disclosed |
| US-5495048-A | ANTICHOLESTEROL AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| JP-H0753479-A | USE OF PHENALKYL AMINE | F HOFFMANN LA ROCHE AG | 1995-02-28 | — | — | JP | disclosed |
| EP-0636367-A1 | Use of phenylalkylamines for producing cholesterol lowering agents | F. HOFFMANN-LA ROCHE AG (CH) | 1995-02-01 | — | — | EP | disclosed |
| EP-0410359-B1 | Substituted aminoalkoxy-benzene-derivatives | HOFFMANN LA ROCHE (CH) | 1994-01-26 | — | — | EP | disclosed |
| US-5214046-A | Synergistic mixtures, inhibitors of sterol biosynthesis | HOFFMANN-LA ROCHE INC. (US) | 1993-05-25 | — | — | US | disclosed |
| US-5106878-A | Synergistic effects with other fungicides | HOFFMANN-LA ROCHE INC. (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0410359-A1 | Substituted aminoalkoxy-benzene-derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-01-30 | — | — | EP | disclosed |