Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 2/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.33 |
| ▸ | DUT | P33316 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3675530 | 0.83 | PTGER4 (0.35) | PDK2PTGER4PTGER3PTGER2 | |
| SCHEMBL1401084 | 0.83 | PDK2 (0.41) | PDK2PTGER4PTGER3PTGER2DUT | |
| SCHEMBL28526467 | 0.83 | DUT (0.33) | PDK2DUT | |
| SCHEMBL21389332 | 0.83 | DUT (0.33) | PDK2DUT | |
| SCHEMBL24795959 | 0.83 | PDK2 (0.41) | PDK2PTGER4PTGER3PTGER2DUT | |
| SCHEMBL24795965 | 0.83 | DUT (0.33) | PDK2DUT | |
| SCHEMBL2850230 | 0.83 | DUT (0.33) | PDK2DUT | |
| SCHEMBL15496410 | 0.81 | GAA (0.32) | PDK2 | |
| SCHEMBL1576228 | 0.80 | DUT (0.34) | DUT | |
| SCHEMBL6436398 | 0.80 | PTGER3 (0.32) | PTGER3PTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130317013-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | BILLOT XAVIER (CA) | 2013-11-28 | — | — | US | disclosed |
| EP-1513589-B1 | 1,5-DISUBSTITUTED PYRROLID-2-ONE DERIVATIVES FOR USE AS EP4 RECEPTOR AGONISTS IN THE TREATMENT OF EYE DISEASES SUCH AS GLAUCOMA | MERCK FROSST CANADA LTD (CA) | 2010-11-10 | — | — | EP | disclosed |
| US-20090258918-A1 | EP4 receptor agonist, compositions and methods thereof | BILLOT XAVIER | 2009-10-15 | — | — | US | disclosed |
| US-20050239872-A1 | 1,5-distributed pyrrolid-2-one derivatives for use as ep4 receptor agonists in the teatment of eye diseases such as glaucoma | MERCK FROSST CANADA LTD. (CA) | 2005-10-27 | — | — | US | disclosed |
| US-20040204590-A1 | Ep4 receptor agonist, compositions and methods thereof | MERCK FROSST CANADA LTD. (CA) | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050239872-A1 | 1,5-distributed pyrrolid-2-one derivatives for use as ep4 receptor agonists in the teatment of eye diseases such as glaucoma | PTGER1, PTGER4, PTGER2 | PDK2 668/4885PTGER4 2/4885PTGER3 4/4885 |
| US-20040204590-A1 | Ep4 receptor agonist, compositions and methods thereof | PTGER4, PTGER1, PTGER3 | PDK2 4029/4885PTGER4 1/4885PTGER3 3/4885 |
| US-20090258918-A1 | EP4 receptor agonist, compositions and methods thereof | PTGER4, PTGER1, PTGER3 | PDK2 4091/4885PTGER4 1/4885PTGER3 3/4885 |
| US-20130317013-A1 | EP4 RECEPTOR AGONIST, COMPOSITIONS AND METHODS THEREOF | PTGER4, PTGER1, PTGER3 | PDK2 4091/4885PTGER4 1/4885PTGER3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.