SCHEMBL3679817

SCHEMBL3679817

O=C(Nc1ccc(Oc2ccc(NC(=O)c3cccc(I)c3)cc2)cc1)c1cccc(I)c1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 2/20 0.64
AR P10275 1/20 0.60
CRHBP P24387 1/20 0.54
CRHR2 Q13324 1/20 0.54
NR1H4 Q96RI1 1/20 0.54
FFAR1 O14842 1/20 0.53
MEN1 O00255 3/20 0.53
KMT2A Q03164 3/20 0.53
TP53 P04637 2/20 0.53
HDAC3 O15379 2/20 0.52
BRAF P15056 2/20 0.52
HDAC4 P56524 2/20 0.52
HDAC1 Q13547 2/20 0.52
HDAC7 Q8WUI4 2/20 0.52
HDAC2 Q92769 2/20 0.52
HDAC10 Q969S8 2/20 0.52
HDAC11 Q96DB2 2/20 0.52
HDAC8 Q9BY41 2/20 0.52
HDAC6 Q9UBN7 2/20 0.52
HDAC9 Q9UKV0 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3669695 0.93 PGR (0.60) PGRARCRHBPCRHR2NR1H4
SCHEMBL1003529 0.88 NPC1 (0.68) PGRARMEN1KMT2ATP53
SCHEMBL3677300 0.87 KMT2A (0.59) MEN1KMT2ATP53HDAC1HDAC2
SCHEMBL1001622 0.85 KMT2A (0.58) MEN1KMT2ATP53NPC1SMN1; SMN2
SCHEMBL15391018 0.84 TRPV1 (0.71) MEN1KMT2ANPC1SMN1; SMN2RAB9A
SCHEMBL9240473 0.84 PGR (0.84) PGRARNR1H4FFAR1MEN1
SCHEMBL18410447 0.83 HDAC1 (0.67) MEN1KMT2AHDAC1HDAC2HDAC8
SCHEMBL32665332 0.83 MEN1 (0.49) PGRARMEN1KMT2ATP53
SCHEMBL12685658 0.83 RHOC (0.57) MEN1KMT2ATP53NPC1SMN1; SMN2
SCHEMBL23091776 0.82 ABL1 (0.65) MEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1329444-B1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORP (JP) 2010-05-05 EP disclosed
EP-1138712-B1 Polyarylene copolymers and proton-conductive membrane JSR CORP (JP) 2006-01-18 EP disclosed
US-6933068-B2 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA (JP) 2005-08-23 US disclosed
US-6833426-B2 A proton-conductive membrane containing the sulfonic acid group-containing polyarylene (co)polymer JSR CORPORATION (JP) 2004-12-21 US disclosed
US-6812290-B2 FOR USE AS ELECTROLYTES JSR CORPORATION (JP) 2004-11-02 US disclosed
US-20030195301-A1 Polyarylene copolymers and proton-conductive membrane JSR CORPORATION (JP) 2003-10-16 US disclosed
US-20030173547-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORPORATION (JP) 2003-09-18 US disclosed
EP-1329444-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR Corporation (JP) 2003-07-23 EP disclosed
US-6555626-B2 Controlled amount of sulfonic acid groups; copolymer of an aromatic compound having a main chain containing electron withdrawing groups and aromatic compounds with no electron withdrawing groups; durability, strength, conductivity JSR CORPORATION (JP) 2003-04-29 US disclosed
US-20020172850-A1 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA, JSR CORPORATION 2002-11-21 US disclosed
US-20010037000-A1 Polyarylene copolymers and proton-conductive membrane JSR CORPORATION (JP) 2001-11-01 US disclosed