Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 7/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PRNP | P04156 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1759301 | 0.88 | PARP1 (0.40) | MAPTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL27963862 | 0.81 | SLC22A12 (0.39) | MAPTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL11893022 | 0.77 | LMNA (0.45) | MAPTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL15351068 | 0.77 | SLC22A12 (0.40) | MAPTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL31596398 | 0.77 | LMNA (0.45) | MAPTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL21801047 | 0.77 | AXL (0.46) | MAPTSMN1; SMN2KDM4EHTTSLC22A12 | |
| SCHEMBL17451250 | 0.76 | IDO1 (0.52) | — | |
| SCHEMBL11273711 | 0.76 | SLC2A1 (0.33) | — | |
| SCHEMBL3649631 | 0.76 | CYP1A2 (0.52) | MAPTSMN1; SMN2KDM4ENPBWR1ALDH1A1 | |
| SCHEMBL4039132 | 0.76 | DAO (0.43) | MAPTSMN1; SMN2KMT2AHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176244-A2 | METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES | E. I. du Pont de Nemours and Company (US) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009025983-A2 | METHOD FOR PREPARING 5-HALOALKYL-4,5-DIHYDROISOXAZOLE DERIVATIVES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-02-26 | — | — | WO | disclosed |