Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 15/20 | 0.55 |
| ▸ | NR3C2 | P08235 | 11/20 | 0.55 |
| ▸ | PGR | P06401 | 4/20 | 0.55 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.45 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4442648 | 0.87 | NR3C1 (0.60) | NR3C1NR3C2PGR | |
| SCHEMBL3656890 | 0.85 | NR3C1 (0.62) | NR3C1NR3C2PGRCYP19A1CYP11B1 | |
| SCHEMBL5780546 | 0.83 | NR3C2 (0.46) | NR3C1NR3C2PGR | |
| SCHEMBL3655647 | 0.79 | NPY5R (0.43) | NR3C1NR3C2PGRMKNK1MKNK2 | |
| SCHEMBL3655849 | 0.79 | NR3C1 (0.43) | NR3C1NR3C2PGR | |
| SCHEMBL5525957 | 0.79 | NR3C1 (0.69) | NR3C1NR3C2PGR | |
| SCHEMBL5801481 | 0.78 | NR3C1 (0.77) | NR3C1NR3C2PGR | |
| SCHEMBL6388026 | 0.78 | NR3C1 (0.89) | NR3C1NR3C2PGR | |
| SCHEMBL5524172 | 0.78 | NR3C1 (0.69) | NR3C1NR3C2PGR | |
| SCHEMBL6386023 | 0.78 | NR3C1 (0.75) | NR3C1NR3C2PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730145-A1 | ALPHA-TRIFLUOROMETHYL ALCOHOLS OR AMINES AS GLUCOCORTICOID MIMETICS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-12-13 | — | — | EP | claimed |
| WO-2005095401-A1 | ALPHA-TRIFLUOROMETHYL ALCOHOLS OR AMINES AS GLUCOCORTICOID MIMETICS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-10-13 | — | — | WO | claimed |
| EP-2190431-A2 | COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST FOR TREATING OR CONTROLLING ANTERIOR-SEGMENT INFLAMMATION | Bausch & Lomb Incorporated (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009023471-A2 | COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST FOR TREATING OR CONTROLLING ANTERIOR-SEGMENT INFLAMMATION | BAUSCH & LOMB INCORPORATED (US) | 2009-02-19 | — | — | WO | disclosed |