SCHEMBL3680993

SCHEMBL3680993

CCOC(=O)C1CC2(CCC1N[C@H](C)c1ccccc1)OCCO2

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.41
TSHR P16473 3/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
KDM4E B2RXH2 3/20 0.40
HPGD P15428 4/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
CCR1 P32246 1/20 0.39
LMNA P02545 1/20 0.38
KCNQ3 O43525 1/20 0.36
KCNQ2 O43526 1/20 0.36
KCNQ4 P56696 1/20 0.36
KCNQ5 Q9NR82 1/20 0.36
MAPT P10636 2/20 0.36
PKM P14618 1/20 0.36
GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3680990 1.00 ALDH1A1 (0.41) ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E
SCHEMBL5033579 1.00 ALDH1A1 (0.41) ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E
SCHEMBL12667950 1.00 ALDH1A1 (0.41) ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E
SCHEMBL4485950 1.00 ALDH1A1 (0.41) ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E
SCHEMBL2993771 1.00 ALDH1A1 (0.41) ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E
SCHEMBL4460390 1.00 ALDH1A1 (0.41) ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E
SCHEMBL4485945 1.00 ALDH1A1 (0.41) ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E
SCHEMBL3745167 1.00 ALDH1A1 (0.41) ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E
Bromide SCHEMBL1770934 0.99 ALDH1A1 (0.40) ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E
SCHEMBL4472116 0.92 ALDH1A1 (0.41) ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2173714-A1 PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY Bristol-Myers Squibb Company (US) 2010-04-14 EP disclosed
WO-2009015166-A1 PIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY BRISTOL-MYERS SQUIBB COMPANY (US) 2009-01-29 WO disclosed