Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.36 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.36 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.36 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5033579 | 0.99 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL12667950 | 0.99 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL3680993 | 0.99 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL4485950 | 0.99 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL2993771 | 0.99 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL4460390 | 0.99 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL4485945 | 0.99 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL3745167 | 0.99 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL3680990 | 0.99 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E | |
| SCHEMBL4472116 | 0.91 | ALDH1A1 (0.41) | ALDH1A1TSHRL3MBTL1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112133-A1 | DIHYDRO PYRROLOQUINOLINE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112133-A1 | DIHYDRO PYRROLOQUINOLINE DERIVATIVES | HRH4, HRH2, BDKRB2 | ALDH1A1 2889/4885TSHR 1310/4885L3MBTL1 4473/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.