Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31731661 | 1.00 | ALDH1A1 (0.37) | ALDH1A1MAPTVCAM1SMN1; SMN2CHUK | |
| SCHEMBL252672 | 0.75 | PGR (0.37) | ALDH1A1MAPTVCAM1MAPK1TSHR | |
| SCHEMBL31731496 | 0.75 | PGR (0.37) | ALDH1A1MAPTVCAM1MAPK1TSHR | |
| SCHEMBL31276651 | 0.74 | MAPT (0.49) | ALDH1A1MAPTVCAM1SMN1; SMN2MAPK1 | |
| SCHEMBL4176261 | 0.74 | MAPT (0.49) | ALDH1A1MAPTVCAM1SMN1; SMN2MAPK1 | |
| SCHEMBL22421151 | 0.74 | ALDH1A1 (0.47) | ALDH1A1MAPTVCAM1CHUKMAPK1 | |
| SCHEMBL4096904 | 0.73 | MAPK1 (0.37) | ALDH1A1MAPTVCAM1SMN1; SMN2MAPK1 | |
| SCHEMBL29739510 | 0.73 | MAPK1 (0.37) | ALDH1A1MAPTVCAM1SMN1; SMN2MAPK1 | |
| SCHEMBL303812 | 0.73 | MAPT (0.44) | ALDH1A1MAPTVCAM1SMN1; SMN2MAPK1 | |
| SCHEMBL4475523 | 0.72 | ALDH1A1 (0.35) | ALDH1A1MAPTGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162433-A2 | 4' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | Memory Pharmaceuticals Corporation (US) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008147812-A2 | 4' SUBSTITUTED COMPOUNDS HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-12-04 | — | — | WO | disclosed |