Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.52 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3687942 | 1.00 | MAPT (0.56) | MAPTLMNAGAAATMSMN1; SMN2 | |
| SCHEMBL3697931 | 0.95 | MAPT (0.57) | MAPTLMNAGAAATMSMN1; SMN2 | |
| SCHEMBL3684123 | 0.95 | MAPT (0.57) | MAPTLMNAGAAATMSMN1; SMN2 | |
| SCHEMBL3694918 | 0.92 | ABCG2 (0.59) | MAPTLMNAGAAATMSMN1; SMN2 | |
| SCHEMBL3697030 | 0.92 | ABCG2 (0.59) | MAPTLMNAGAAATMSMN1; SMN2 | |
| SCHEMBL3682377 | 0.88 | PDE4A (0.56) | MAPTLMNAGAAATMSMN1; SMN2 | |
| SCHEMBL3689543 | 0.87 | ABCG2 (0.60) | MAPTLMNAGAAATMSMN1; SMN2 | |
| SCHEMBL3688287 | 0.87 | ABCG2 (0.60) | MAPTLMNAGAAATMSMN1; SMN2 | |
| SCHEMBL3694922 | 0.86 | MAPT (0.57) | MAPTLMNASMN1; SMN2ABCG2PDE4A | |
| SCHEMBL4851327 | 0.85 | MAPT (0.59) | MAPTLMNAGAAATMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642367-B2 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2010-01-05 | — | — | US | disclosed |
| US-20060235073-A1 | Diamino-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2006-10-19 | — | — | US | disclosed |